Now showing items 1-20 of 115

    An Omics World: Colonization and Adaptive Processes of Styela plicata 

    Galià Camps, Carles (Date of defense: 2024-01-22)

    [eng] In the last decades biological invasions have emerged as a global concern, as they impact local biodiversity by disrupting ecosystem functioning and ultimately affect human health, economy and wellness. In a climate ...

    Analysis and coordination of different mechanisms controlling tube elongation during the development of the embryonic system in Drosophila melanogaster 

    Olivares Castiñeira, Ivette (Date of defense: 2017-12-20)

    The tracheal (respiratory) system of the Drosophila embryo is a network of interconnected epithelial tubes that supplies and exchanges the gas to maintain the homeostasis of the entire organism. Maintaining a controlled ...

    Analysis of the contribution of linker histone H1 to the dynamics of RNA:DNA hybrids 

    Casas Lamesa, Anna (Date of defense: 2018-11-21)

    Histone H1 is a key determinant of higher-order chromatin structures and for a long time it has been considered a main transcriptional repressor. So consistent with its biochemical properties, the absence of histone H1 was ...

    Analysis of the genomic distribution of linker histone H1 variants in human = Anàlisi de la distribució genòmica de les variants d'histona H1 en humans 

    Izquierdo Bouldstridge, Andrea (Date of defense: 2018-03-13)

    Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Using variant-specific antibodies to H1 and hemagglutinin-tagged recombinant H1 variants expressed in breast ...

    Análisis de las diferencias entre células progenitoras y no progenitoras en el sistema traqueal de Drosophila melanogaster 

    Pino, V. Beatriz (Date of defense: 2022-07-15)

    In the Drosophila larva, most of the juvenile tissues are made up of large polyploid cells fated to die during metamorphosis stage. The dorsal trunk of the tracheal system is composed mainly of these cells, apart from the ...

    Análisis del anudamiento del ADN intracelular 

    Valdés Gutiérrez, Antonio (Date of defense: 2019-03-01)

    La mayoría de las transacciones del genoma producen estrés topológico en el ADN, que se reduce gracias a la acción de las topoisomerasas. Por ejemplo, durante la transcripción y replicación del ADN, las topoisomerasas I y ...

    Aplicació de les noves tecnologies de seqüenciació massiva al diagnòstic molecular de la malaltia de von Willebrand. Estudi de grans cohorts i anàlisi de la correlació genotip-fenotip 

    Borràs Agustí, Nina (Date of defense: 2018-10-24)

    La malaltia de von Willebrand (VWD) és la patologia hemorràgica hereditària més freqüent a la població i està causada per dèficits quantitatius o qualitatius del factor von Willebrand (VWF). Segons el defecte, es distingeixen ...

    Aplicació de tècniques de seqüenciació massiva a l´estudi de virus potencialment contaminants d´aigües i/o aliments 

    Fernández Cassi, Xavier (Date of defense: 2017-07-19)

    L’objectiu global plantejat en aquesta tesi ha estat l’anàlisi dels patògens virals que a través de l’aigua residual, poden contaminar l’aigua de reg i els aliments. Les aigües regenerades i les aigües de riu són importants ...

    Aplicación de técnicas moleculares y químicas al estudio de la dieta, migración y estructura poblacional del rorcual común de Islandia 

    García Vernet, Raquel (Date of defense: 2022-05-06)

    El objetivo global de esta tesis es ampliar el conocimiento sobre la biología y ecología del rorcual común, con foco principal en la población de rorcual común de Islandia. Dadas las numerosas incógnitas que siguen existiendo ...

    Autonomous and non-autonomous regulation on planarian growth and regeneration: Smed-bls, canonical Wnt signalling and Fox family 

    Pascual Carreras, Eudald (Date of defense: 2020-01-10)

    Development requires an increment of cell growth and cell number, concomitant to a tightly control of cell differentiation. Thanks to cell communication, cells can be spatiotemporal patterned to acquire the required fate. ...

    Bacterial metabolic networks channeling the biodegradation of PAHs in contaminated soils. Oxy-PAHs as catabolic nodes 

    Jiménez Volkerink, Sara Nienke (Date of defense: 2021-11-30)

    Polycyclic aromatic hydrocarbons (PAHs) are major environmental pollutants in a number of point source contaminated sites, where they are found embedded in complex mixtures containing different polyaromatic compounds. The ...

    Bacteriófagos y movilización de genes de resistencia a antibióticos desde una perspectiva One-Health 

    Blanco Picazo, Pedro (Date of defense: 2022-12-16)

    [spa] En las últimas décadas la resistencia a antibióticos se ha convertido en uno de los principales problemas de salud pública a nivel global, y desde la iniciativa One-Health se han propuesto afrontar este problema, ...

    Bioequivalencia promedio escalada 

    Muñoz Gutiérrez, Joel Alejandro (Date of defense: 2017-09-14)

    La agencia europea del medicamento, EMA, y la estadounidense FDA, propusieron límites de bioequivalencia (BE) “escalada” para facilitar la declaración BE de genéricos de drogas de alta variabilidad (HVD). La ...

    Bioreduction of iron (hydr)oxides from mine tailings under marine conditions 

    Benaiges-Fernandez, Robert (Date of defense: 2021-03-26)

    Mining industry faces environmental problems concerning waste management. Given the environmental issues associated with storage of mine wastes on land, one disposal option that has gained attraction is submarine tailings ...

    Capsaspora owczarzaki as a unicellular model to study the pre-metazoan integrin adhesome 

    Parra Acero, Helena (Date of defense: 2019-02-08)

    Animal multicellular structure depends on three general mechanisms: cell adhesion, cell communication and cell differentiation. Some of these mechanisms were thought to be specific to animals. Genome sequencing of unicellular ...

    Caracterización del mecanismo molecular por el cual la vía WNT/Bcatenina especifica el eje anteroposterior y controla la organogénesis en las planarias 

    Sureda Gómez, Miquel (Date of defense: 2017-09-15)

    La vía Wnt canónica es una vía de señalización muy conservada a lo largo de la evolución de los animales. Esta vía controla múltiples procesos como es la especificación del eje anteroposterior o el destino celular durante ...

    Characterization of emerging novel human astrovirus: form bedside to bench 

    Vu Cantero, Diem-Lan (Date of defense: 2020-01-20)

    Novel human astrovirus (HAstV) are enteric virus belonging to the Astroviridae family and were discovered 10 years ago by high-throughput sequencing. They are divided in two different clades, the HAstV-MLB including 3 ...

    Characterization of genetic factors associated with melanoma susceptibility and prognosis 

    Potrony Mateu, Míriam (Date of defense: 2018-09-28)

    Melanoma is the malignant tumor arising from melanocytes and is the most aggressive of the common skin cancers. Melanoma is the tumor with the highest heritability (58%) and around 10% of cases occur in a familial context. ...

    Chitin deposition in the apical extracellular matrices of Drosophila melanogaster: a focus on Expansion, Rebuf and Chitin Synthases 

    De Giorgio, Ettore (Date of defense: 2022-03-18)

    Chitin has a recognised importance in physiology but also as a biomaterial. In insects, it is the principal component of the apical extracellular matrix of epidermis, tracheae, foregut and hindgut. In these compartments, ...

    Combining exome sequencing and functional studies to identify causal genes of ultra-rare neurodevelopmental disorders 

    Castilla-Vallmanya, Laura (Date of defense: 2021-11-04)

    Neurodevelopmental disorders (NDDs) are a group of chronic diseases in which the development of the central nervous system is impaired, resulting in disability at the neuropsychiatric, motor and/or intellectual level. Some ...