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Charting the alternative splicing vulnerabilities of cancer
Cancer co-opts alternative splicing to select isoforms that promote disease initiation, progression, and persistence. Drugs targeting either cancer driver splicing factors or specific splicing events can hamper the disease. ...
Attributing heat-related mortality to climate change
Climate change significantly exacerbates public health risks, particularly heat-related mortality. This PhD thesis examines the impact of human-induced climate change on heat-related deaths in Europe, focusing on regional ...
Evaluación del valor pronóstico de la ecografía pulmonar en el infarto agudo de miocardio con elevación del ST (LUS-AMI)
La insuficiencia cardíaca (IC) es un factor pronóstico crucial en pacientes con infarto agudo de miocardio con elevación del ST (IAMEST). La ecografía pulmonar es una técnica ampliamente estudiada en pacientes con insuficiencia ...
New insights into the clinical utility of LMO2
This thesis offers novel information on the clinical utility of LMO2, shown in three different studies. In the first one, we generated a round-robin testing validating the interobserver and interlaboratory reproducibility ...
A novel computational framework for identifying epileptogenic networks based on functional connectivity changes
Esta tesis se centra en mejorar la precisión de los objetivos quirúrgicos en pacientes con epilepsia resistente a los fármacos. Las redes cerebrales epileptogénicas exhiben cambios significativos en la conectividad durante ...
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