Burguera Hernández, Demian (Date of defense: 2017-09-22)
In the present work, we studied the evolution of alternative splicing (AS) from different perspectives. First, we performed a preliminary analysis where we identified alternative exons with tissue-specific ...
Jiménez Panizo, Alba (Date of defense: 2021-12-14)
El receptor de glucocorticoides (GR) es un factor de transcripción que se expresa de forma ubicua y controla procesos esenciales para la vida como el metabolismo, la inflamación y la homeostasis. Aunque ...
Romero Durana, Miguel Alfonso (Date of defense: 2018-11-26)
Proteins play a crucial role in virtually every biological process taking place within our cells. Most of the times, proteins do not participate in these processes alone but forming complexes of two or ...
Martínez Martínez, Arturo (Date of defense: 2022-12-02)
[spa] HERC1 es una E3 ubicuitina ligasa de la familia HECT. Mutaciones en el gen de HERC1 han sido relacionadas con diferentes tipos de cánceres y enfermedades neurodegenerativas. En esta tesis, ...
Loren Parrondo, Guillem (Date of defense: 2023-09-15)
[eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing ...
Caballero Díaz, Daniel (Date of defense: 2018-02-09)
Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, ...
Mas Moruno, Carlos (Date of defense: 2009-03-05)
La sepsis es un síndrome muy complejo de definir, diagnosticar y tratar. La patología de la sepsis se deriva de una respuesta perjudicial del organismo a una infección. La exposición a endotoxinas ...
Candotti, Michela (Date of defense: 2016-12-09)
This work aims to analytically understand the impact of two diametric opposite environments on protein structure and dynamics and compared them to the most common solvent on earth: water. The first ...
Sammito, Massimo Domenico (Date of defense: 2015-06-22)
ARCIMBOLDO is an ab initio phasing method for macromolecular crystallographic X-ray diffraction data, which combines location of model fragments such as polyalanine α- helices with the program PHASER ...
Dyson Coral, Silvia (Date of defense: 2021-12-14)
Topoisomerase II often produces DNA knots and catenates when its DNA strand passage activity equilibrates the topology of intracellular DNA. However, these DNA entanglements are detrimental for the ...