Now showing items 67-86 of 143

    Marcatge amb 15N de purines i disseny de nous inhibidors del VIH-I 

    Terrazas Martínez, Montserrat (Date of defense: 2006-07-13)

    En la present Tesi s'han intentat desenvolupar noves metodologies que permetin modificar les nucleobases puríniques dels nucleòsids amb dues intencions clarament diferenciades: d'una banda, el seu marcatge amb 15N, per tal ...

    Marine Natural Products. Synthesis and structure determination 

    Lorente Crivillé, Adriana (Date of defense: 2014-07-18)

    Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...

    Mayotlide: synthetic approaches and structural elucidation 

    Herraiz Cobo, Jesús (Date of defense: 2017-07-13)

    Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy revealed the presence ...

    Modified oligonucleotides for triple helix studies and for the obtention of structures with biomedical and technological interest 

    Alvira Torre, Margarita (Date of defense: 2010-10-25)

    Oligonucleotides are short fragments of DNA (10-100nt) which are of great interest because their applications in molecular biology, biomedicine and nanotechnology. As a result of their ability to base pairing, oligonucleotides ...

    Molecular recognition in gas phase: theoretical and experimental study of non-covalent protein-ligand complexes by mass-spectrometry 

    Dyachenko, Andrey (Date of defense: 2013-04-15)

    In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...

    Multifunctional self-stratified polyurethane-polyurea nanosystems for smart drug delivery 

    Rocas Alonso, Pau (Date of defense: 2016-02-25)

    This thesis, entitled "Multifunctional Self-stratified Polyurethane-Polyurea Nanosystems for Smart Drug Delivery" is structured as a compendium of publications, being organized around a methodological synthetic patent and ...

    A Multiplexed diagnostic approach for cardiovascular disease biomarkers 

    Colom Sanmartí, Glòria (Date of defense: 2016-01-28)

    In the course of this thesis, the optimal epitopes for the subsequent polyclonal rabbit antibody production for cTnI and NT-proBNP have been studied and chosen. cTnI and NT-proBNP are the most relevant cardio-specific ...

    N-Myristoylation-Dependent c-Src Interactions 

    Le Roux, Anabel-Lise (Date of defense: 2015-11-18)

    c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...

    New Orthogonal Strategies for Peptide Synthesis 

    Góngora Benítez, Miriam (Date of defense: 2013-02-08)

    Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during peptide elongation, and ...

    New Protecting Groups for the Synthesis of Complex Peptides 

    Isidro Llobet, Albert (Date of defense: 2008-05-13)

    The increasing importance of peptides as drugs creates the necessity of new methodologies for the synthesis of complex peptides. This PhD thesis has been focused on the development of new protecting groups (including new ...

    New strategies based on nanosystems to facilitate the crossing through biological barriers 

    Garcia Garcia, Josep (Date of defense: 2016-07-04)

    During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...

    NMR in drug discovery. From screening to structure-based design of antitumoral agents 

    Rodríguez Mías, Ricard Aleix (Date of defense: 2006-10-05)

    Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present thesis we propose ...

    Nous ciclitols com a inhibidors de la glucocerebrosidasa. Aplicació al disseny de xaperones farmacològiques per al tractament de la malaltia de Gaucher 

    Trapero Puig, Ana (Date of defense: 2011-03-21)

    Els malalts de Gaucher manquen de l’activitat normal de l’enzim lisosomal Glucocerebrosidasa (GCase), una β–glucosidasa que hidrolitza l’enllaç glicosídic entre la glucosa i la ceramida, i són incapaços de metabolitzar la ...

    Nous reactius d’acoblament per a la síntesi de pèptids basats en 2-ciano-2-hidroxiimino acetat d’etil (Oxyma) com a additiu 

    Subirós Funosas, Ramon (Date of defense: 2011-07-21)

    Els pèptids són biopolímers naturals amb una importància cabdal en el cos humà, actuant com a neurotransmissors, endorfines o hormones. Recentment, s’han descobert propietats molt interessants de pèptids amb aplicacions ...

    Novel Specific Receptor‐based Techniques for Antibiotic Residue Analysis 

    Adrián Izquierdo, Javier (Date of defense: 2012-09-28)

    The indiscriminate and/or improper use of veterinary drugs is the cause of potential adverse health effects due to the risk of entering into the food chain and the appearance of residues in food products of animal origin. ...

    Noves aplicacions sintètiques d’al•lens per a l’obtenció d’aminopoliols i heterocicles nitrogenats 

    Rodríguez Ramírez, Aleix (Date of defense: 2014-10-31)

    En aquesta Tesi, s’ha estudiat l’aplicació dels al•lens en dues metodologies: el procés tàndem d’hidroboració d’al•lens i posterior addició a aldehids i la inserció d’al•lens a benzilamines i feniletilamines catalitzada ...

    Noves aproximacions a la lactacistina i altres metabòlits bioactius a partir d'1,4 i 1,3- diols 

    Ortiz Gil, Jordi (Date of defense: 2006-10-31)

    En la primera part d'aquesta tesi s'ha portat a terme un ampli estudi de la reacció d'addició d'acetilurs de zinc derivats d'1-alquin-3-ols quirals enriquits enantiomèricament per a obtenir 2-alquin-1,4-diols, tot adaptant ...

    Noves aproximacions per a la detecció de microorganismes patògens 

    Pastells Díez, Carme (Date of defense: 2016-01-19)

    Aquesta tesi s'ha focalitzat en el desenvolupament de noves eines immunoquímiques per al diagnòstic de malalties infeccioses amb l'objectiu d'incrementar l'eficiència dels actuals mètodes de diagnòstic. Concretament, aquesta ...

    Noves estructures basades en aminoàcids trifuncionals: foldàmers i quimioteques basades en derivats de prolina 

    Farrera Sinfreu, Josep Maria (Date of defense: 2006-07-19)

    Les molècules ramificades poden jugar un paper clau en la síntesi en fase sòlida de compostos amb una elevada complexitat estructural. En aquest sentit i concretament en la síntesi de pèptids i peptidomimètics, els aminoàcids ...

    Noves modificacions estructurals en nucleòsids i macròlides 

    Costa i Arnau, Anna M. (Date of defense: 1999-06-28)

    Esta Tesis Doctoral se centra en la preparación de moléculas con potencial actividad terapéutica, dentro del campo de los nucleósidos y las macrólidas. Así, en el primer capítulo se han preparado 3' -pirimidinilnucleósidos ...