Schroeder, Michael Philipp (Date of defense: 2014-11-21)
Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation ...
Rodríguez Sodupe, Pau (Date of defense: 2022-03-09)
The profiling of circulating-tumor DNA (ctDNA) in blood plasma, often known as liquid biopsy, has recently been of great interest in cancer research. This minimally-invasive strategy relies on the fact ...
Singh, Babita (Date of defense: 2017-05-11)
RNA processing and their alterations are determinant to understand normal and disease cell phenotypes. In particular, specific alterations in the RNA processing of genes has been linked to widely accepted ...
Caballero de la Torre, María (Date of defense: 2021-09-09)
Retinoblastoma protein (RB) is a negative regulator of the cell cycle. In response to environmental stress, p38 MAPK phosphorylates RB in the N-terminal region, increasing the affinity of RB for E2F, ...
Pavlovic, Milica (Date of defense: 2014-03-11)
El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, ...
García Parra, Jetzabel (Date of defense: 2012-06-21)
Breast cancer is the main cause of cancer death in women. Improved treatments, prevention programs and earlier detection are reducing the rate of death; however, there is still a high percentage of ...
Pérez Llamas, Christian (Date of defense: 2015-12-18)
Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are ...
Sánchez Osuna, María (Date of defense: 2014-12-19)
Glioblastoma multiforme, one of the most aggressive and lethal tumors, is characterized by a high apoptosis resistance. This doctoral thesis addresses the biochemical behavior of diverse glioblastoma ...
Stanisavljević, Jelena (Date of defense: 2014-07-17)
Carcinomas initiate their invasion hijacking the innate plasticity of both epithelial cells and mesenchymal stromal cells in a reciprocal way. Chemical and mechanical dialogue between stromal fibroblasts ...
Trincado Alonso, Juan Luis (Date of defense: 2019-01-28)
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main ...