La UPF és una universitat pública, internacional i intensiva en recerca que està al nivell de les millors universitats europees. Amb excel·lents indicadors de producció científica com és el cas de les tesis doctorals en accés obert.

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Si sou doctor o doctora de la Universitat Pompeu Fabra i voleu publicar la vostra tesi a TDX, contacteu amb CAU . Per a més informació consulteu Publicació de tesis a TDX. i les preguntes més freqüents

Recent Submissions

Deciphering lymphoma-specific DNA methylation alterations in healthy B cells: a single-cell multiomics study 

Bianchi, Agostina (Date of defense: 2024-12-03)

Recent studies have shown that clones harboring cancer driver mutations colonize our tissues as we age. It remains to be determined whether the same is true for epigenetic alterations, specifically DNA methylation (DNAm) ...

Dissecting motor behaviour alterations in Parkinson's disease using genetically modified zebrafish models 

Tzotzolaki, Tanita Maria (Date of defense: 2024-12-02)

Los trastornos neurodegenerativos como la enfermedad de Parkinson (EP) implican la degeneración progresiva del sistema nervioso, lo que provoca alteraciones tanto motoras como cognitivas. La EP afecta a millones de personas ...

Decoding the regulatory grammar of hematopoiesis using synthetic enhancers 

Frömel, Robert Udo (Date of defense: 2024-11-29)

During cellular differentiation, gene regulatory elements (GREs) play a crucial role in converting expression gradients of transcription factors (TF) into precise target gene activation. However, the underlying rules are ...

Novel transcription mechanisms used by dendritic cells in the tumor immune microenvironment 

Krasko, Anastasia (Date of defense: 2024-11-29)

Interferon is essential for eliciting adaptive immunity against cancer cells. Type I interferon (IFNI) activates proinflammatory responses in dendritic cells (DCs) and this promotes specific anti-tumor T cell responses. ...

Equivariant graph neural networks in drug discover: from property prediction to molecule generation 

Cremer, Julian (Date of defense: 2024-11-28)

Advancements in machine learning have revolutionized various aspects of drug discovery, from molecular property prediction to de novo design. This thesis presents a comprehensive exploration of equivariant graph neural ...

When P. falciparum meets the brain microvasculature: a 3D blood-brain barrier model to study cerebral malaria 

Piatti, Livia (Date of defense: 2024-11-28)

La alteración de la barrera hematoencefálica está relacionada con la malaria cerebral, una complicación de la infección por Plasmodium falciparum asociada con la acumulación del parásito en los vasos sanguíneos cerebrales. ...

Machine learning methods of property prediction in drug discovery 

Schapin, Nikolai (Date of defense: 2024-11-28)

Molecular properties are highly important in drug discovery with binding affinity being crucial for selecting hit and lead candidates. Existing machine learning models often lack speed for large-scale screening or lack ...

Silence speaks volumes a fine-frained analysis of pause production reveals group differences on the spectrum of cognitive decline 

Lofgren, Mary (Date of defense: 2024-11-18)

Previous evidence suggests that increased pause production in spontaneous speech can indicate cognitive decline in Alzheimer’s disease (AD), and that this may depend on the linguistic context of the pause, such as syntactic ...

Turismo transmedia. Análisis, evaluación y caracterización de experiencias transmedia para el diseño de nuevos espacios turísticos 

Casellas Oriol, Sílvia (Date of defense: 2024-11-08)

Esta tesis tiene como objeto de estudio el efecto de las narrativas transmedia en la experiencia turística y su capacidad de diseñar nuevos espacios turísticos en un contexto de convergencia cultural y reconfiguración del ...

Sostenibilidad de los medios de comunicación investigación conceptual y operacional sobre la relevancia y el engagement 

Castells Fos, Llúcia (Date of defense: 2024-11-07)

La sostenibilidad económica de los medios de comunicación es una prioridad para las sociedades democráticas. Ahora bien, en un entorno digital de alta competencia, es un hecho establecido que, por un lado, los medios han ...

CEBPa is an orchestrator of trophectoderm specification 

Wei, Xiao (Date of defense: 2024-11-27)

La bifurcación entre trofoectodermo y la masa celular interna es la decisión de desarrollo más temprana, pero cómo se inicia y en qué etapa embrionaria ocurre no se entiende completamente. Aquí describimos que el factor ...

Synaptic transcriptomic changes sensitive to pharmacological approaches in fragile X syndrome: from mouse to human 

Reyes Ramírez, Lucía de los (Date of defense: 2024-11-26)

Fragile X syndrome (FXS), the most common monogenic cause of intellectual disability and autism, is characterized by impairment in cognitive function and synaptic plasticity. Several preclinical studies in animal models ...

Evaluation of tumor mutational burden in follicular lymphoma 

Lafuente Sánchez, Marta (Date of defense: 2024-11-25)

El linfoma folicular (LF) es el subtipo más frecuente de linfoma no-Hodgkin indolente, caracterizado por un buen pronóstico a pesar de considerarse incurable. Sin embargo, algunos pacientes presentan un curso clínico más ...

Empowering educators' inspiration during the learning design process with citizen science data and technology-enhanced learning 

Calvera Isabal, Miriam (Date of defense: 2024-11-19)

The creation of learning designs (LD) represents a pivotal aspect of pedagogical practice, as it entails the integration of subject-matter knowledge with the pedagogical expertise of individual educators. Furthermore, ...

Manual d'apocalíptica contemporània: Epistemologia, ontologia i ètica per a temps de tribulació 

Calvera Cabeza, Ignasi (Date of defense: 2024-06-05)

The most recent technological advances, especially in the field of artificial intelligence (AI), have generated a new eschatological framework; now, however, of a secular nature. Philosophers, politicians, engineers, ...

Fixing a broken heart: Zebrafish as a model for heart regeneration drug discovery 

Apolínová, Kateřina (Date of defense: 2024-11-20)

Myocardial infarction (MI) remains a leading cause of mortality, with currently available treatments addressing symptoms rather than promoting heart muscle regeneration. Cardiac regeneration strategies, inspired by ...

Genomic analysis of demographic changes in Southern Europe during Roman colonization and Late Antiquity 

Carrión, Pablo (Date of defense: 2024-11-15)

The expansion of the Roman Empire throughout the Mediterranean region and West Eurasia severely shaped the world culturally and politically. This period has been traditionally studied and researched by historians and ...

Temperature impacts on mortality at different spatial and temporal scales 

Quijal-Zamorano, Marcos (Date of defense: 2024-11-14)

This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...

High resolution 3D modelling of lumbar spine from MRI using deep learning 

Ranganathan, Sai Natarajan Thrissur (Date of defense: 2024-10-29)

This thesis addresses the growing problem of degenerative disorders of the intervertebral discs (IVD). Intervertebral Disc Degeneration (IDD) represents a progressive degradation of the IVDs compromising their biomechanical ...

Phylogenetic applications of ancient protein sequences 

Krüger, Johanna (Date of defense: 2024-11-11)

The resilience of proteins against degradation makes them the longest surviving resource for genomic information. Knowing how much information we can obtain from an ancient sample is crucial because most sampling strategies ...

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