Universitat de Girona
Now showing items 83-102 of 111
En aquesta tesi s'han dut a terme dos tipus d'estudis diferents. L'objectiu del primer era la preservació del semen de porcí a 15ºC i el del segon eren els co-cultius homòlegs de cèl·lules epitelials de l'oviducte i ...
Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...
La DM 2 és una malaltia multifactorial i multigènica. Aquest fet condueix a l'estudi de molts gens i proteïnes susceptibles d'estar implicades amb la DM 2. Algunes d'aquestes proteïnes i gens estan associats a un estat ...
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...
For many years, reproductive outcomes were considered as being solely determined by the genome of oocytes and sperm. Yet, in the last decades, many other female and male factors have also been found to be relevant. Focusing ...
The overuse of antibiotics has led to the selection of resistant strains. This thesis investigated the occurrence of antibiotic resistance genes (ARGs) in aquatic microbial communities influenced by anthropogenic activities. ...
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...
Utilitzant temperatura i pressió com a agents desnaturalitzants s'ha explorat la contribució a l'estabilitat de diferents residus del principal nucli hidrofòbic de la RNasa A. Aquests resutats suggereixen que el principal ...
The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...
The physical demands (high-intensity running and sprinting) of football match-play place footballers at increased risk of hamstring injuries. Some of the negative effects of a hamstring injury such as neuromuscular ...
The spermatozoon is a highly specialised cell that travels along the female reproductive tract to deliver its genetic information into the oocyte. During this journey, the interaction with the varying environment is crucial ...
In Spain, as well as in the rest of Europe, livestock farming represents a substantial part of economy; thus, it is necessary to ensure an optimal breeding of the main farm animals, including swine and cattle. In order to ...
Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it constitutes a good ...
Amb la finalitat d'aprofundir en les bases moleculars de la citotoxicitat de les ribonucleases pancreàtiques, es van construir variants derivades de l'HP-RNasa seguint dues estratègies. En la primera, es van generar variants ...
The answer to whether or not, human pancreatic ribonuclease may have a diagnostic value as a serum marker of pancreatic disease, depend upon the specific detection of ribonucleases originated in pancreas amogn those ...
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
Male fertilising capacity has traditionally been predicted by the assessment of sperm concentration, motility and morphology. During the last few decades, however, research has been particularly focused on the analysis of ...
Es presenta el model atòmic a 4.5 Å de DnaB, la principal helicasa replicativa bacteriana, d'Aquifex aeolicus. És un anell hexamèric de 100 Å d'amplada i 80 Å d'alçada amb dues capes de simetria diferenciada, la dels dominis ...
