Now showing items 89-108 of 111

    Occurrence of antibiotic resistance genes in aquatic microbial communities exposed to anthropogenic activities 

    Marti Serrano, Elisabet (Date of defense: 2014-03-07)

    The overuse of antibiotics has led to the selection of resistant strains. This thesis investigated the occurrence of antibiotic resistance genes (ARGs) in aquatic microbial communities influenced by anthropogenic activities. ...

    Pancreatic cancer markers based on aberrant glycosylation of serum proteins 

    Balmaña Esteban, Meritxell (Date of defense: 2016-07-07)

    Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...

    Paper del nucli hidrofòbic principal de la RNasa A en el plegament i desplegament induïts per pressió i temperatura 

    Font i Sadurní, Josep (Date of defense: 2006-06-02)

    Utilitzant temperatura i pressió com a agents desnaturalitzants s'ha explorat la contribució a l'estabilitat de diferents residus del principal nucli hidrofòbic de la RNasa A. Aquests resutats suggereixen que el principal ...

    Phylogeographical analysis of two aristed shrimps, Aristeus antennatus and Aristaemorpha foliacea (Crustacea: Aristeidae), with implications for resource conservation 

    Fernández Hernández, Maria Victoria (Date of defense: 2012-11-28)

    The conservation of species relies on a deep knowledge of biology of the species concerned, as well as on the identification of reproductively isolated units, which are genetically different from one other (genetic stocks). ...

    Physical performance and hamstring injury risk factors during the off-season period in footballers: inertial flywheel versus gravity-dependent resistance training methods 

    Vicens Bordas, Jordi (Date of defense: 2021-06-16)

    The physical demands (high-intensity running and sprinting) of football match-play place footballers at increased risk of hamstring injuries. Some of the negative effects of a hamstring injury such as neuromuscular ...

    Physiological role of mitochondrial and plasma membrane channels in sperm 

    Delgado Bermúdez, Ariadna (Date of defense: 2022-07-28)

    The spermatozoon is a highly specialised cell that travels along the female reproductive tract to deliver its genetic information into the oocyte. During this journey, the interaction with the varying environment is crucial ...

    Physiological role of sperm and seminal plasma proteins along the female reproductive tract in livestock 

    Recuero Cobos, Sandra (Date of defense: 2022-04-01)

    In Spain, as well as in the rest of Europe, livestock farming represents a substantial part of economy; thus, it is necessary to ensure an optimal breeding of the main farm animals, including swine and cattle. In order to ...

    Producció i caracterització de variants de la regió C-terminal de la ribonucleasa A. Importància d'aquesta regió sobre l'estabilitat de l'enzim 

    Coll Constans, M. Gràcia (Date of defense: 2000-03-31)

    Bovine pancreatic ribonuclease A (RNase A, EC 3.1.27.5) has been extensively studied from the structural, mechanistic and functional points of view. Within the protein folding context, it constitutes a good ...

    Producció i caracterització de variants de la ribonucleasa pancreàtica humana dissenyades per a adquirir propietats citotòxiques 

    Bosch i Grau, Montserrat (Date of defense: 2003-12-18)

    Amb la finalitat d'aprofundir en les bases moleculars de la citotoxicitat de les ribonucleases pancreàtiques, es van construir variants derivades de l'HP-RNasa seguint dues estratègies. En la primera, es van generar variants ...

    Purificació, caracterització i clonatge de la ribonucleasa de pàncreas humà 

    Ribó i Panosa, Marc (Date of defense: 1994-12-16)

    The answer to whether or not, human pancreatic ribonuclease may have a diagnostic value as a serum marker of pancreatic disease, depend upon the specific detection of ribonucleases originated in pancreas amogn those ...

    Regulation and function of silayltransferases in pancreatic cancer 

    Bassagañas i Puigdemont, Sònia (Date of defense: 2014-12-03)

    Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and ...

    Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida 

    Díaz Roldán, Ferran (Date of defense: 2023-07-03)

    Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...

    Relevance of sperm chromatin protamination, condensation and DNA integrity for sperm function and fertility: the role of toroid linker regions 

    Viñolas Vergés, Estel (Date of defense: 2023-07-27)

    Male fertilising capacity has traditionally been predicted by the assessment of sperm concentration, motility and morphology. During the last few decades, however, research has been particularly focused on the analysis of ...

    Resolució de l'estructura tridimensional de l'helicasa hexamètrica DnaB 

    Arribas Bosacoma, Raquel (Date of defense: 2009-07-22)

    Es presenta el model atòmic a 4.5 Å de DnaB, la principal helicasa replicativa bacteriana, d'Aquifex aeolicus. És un anell hexamèric de 100 Å d'amplada i 80 Å d'alçada amb dues capes de simetria diferenciada, la dels dominis ...

    Role of alpha 2,3-sialyltransferases ST3Gal III and ST3Gal IV in pancreatic ductal adenocarcinoma 

    Pérez Garay, Marta (Date of defense: 2011-02-07)

    Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal IV), están directamente ...

    Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions 

    Muñoz San Martín, María (Date of defense: 2021-09-15)

    Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...

    Signatures bacterianes com a eines de diagnòstic diferencial i monitoratge de les malalties inflamatòries intestinals 

    Amoedo Cibeira, Joan (Date of defense: 2020-12-15)

    Inflammatory Bowel Disease (IBD) is a group of immune-based pathologies that affect the digestive tract, causing chronic inflammatory diseases processes. In recent years, the microbial communities that inhabit the human ...

    Structural and functional characterization of Apoptin and design of a monomeric variant with antitumor activity 

    Ruiz Martínez, Santiago (Date of defense: 2016-07-08)

    The main aim of the present study is to characterize the biological and biophysical properties of Apoptin, a viral protein that selectively induces apoptosis of a wide range of tumor cells. Apoptin has been produced and ...

    Study of the anticancer activity of a nuclear directed HP-RNase variant and different metal-based compounds 

    Bravo Bonilla, Marlon Rolando (Date of defense: 2022-06-16)

    Cancer is the leading cause of death due to non-communicable diseases worldwide. Despite the advances in the development of new antitumor drugs, there are still problems such as the resistance that tumor cells acquire ...

    Towards the implementation of a biotechnology for biogas upgrading: role of bacteria in siloxane removal 

    Boada Cahueñas, Ellana (Date of defense: 2020-07-20)

    Biogas is a highly recognized alternative to fossil fuels towards a sustainable energy production. Massive use of biogas depends on the removal of contaminants that may affect performance of processing equipment and energy ...