A bioengineering approach for corneal endothelial regeneration. 

    Bosch Canals, Begoña María (Date of defense: 2019-07-16)

    Nowadays, there are approximately 10 million people worldwide with visual impairment due to corneal diseases. Currently, the main therapeutic solution is the transplant of a donor's cornea. The great majority of transplants ...

    Caracterización cuantitativa de las ciclinas de la fase G1 del ciclo celular en Saccharomyces cerevisiae 

    Bállega Moreno, Elisabet (Date of defense: 2017-07-11)

    Saccharomyces cerevisiae és un microorganisme unicel·lular eucariota que per presentar el seu genoma totalment seqüenciat, gran facilitat de manipulació en el treball de laboratori, ja que molts dels seus gens es troben ...

    Caracterización de complejos CDK-Ciclina atípicos humanos 

    Quandt Herrera, Eva (Date of defense: 2017-11-16)

    La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales reguladores del ...

    Caracterización molecular de nuevos substratos de la CDK Pho85 

    Ricco Pacheco, Natalia (Date of defense: 2013-07-23)

    La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de las células y retrasa ...

    CDK-mediated phosphorylation of Yku80 and its role in DNA repair 

    Carballar Ruiz, María de los Reyes (Date of defense: 2021-02-25)

    DNA double-strand breaks (DSBs) are considered the most deleterious lesions of DNA and they are repaired by means of two main mechanisms: homologous recombination (HR) and non-homologous endjoining (NHEJ). These mechanisms ...

    Characterization of new mutations in transferrin, DMT1 and SEC23B causing rare iron metabolism-related diseases; and the discovery of RACGAP1 as the gene responsible for autosomal recessive congenital dyserythropoietic anaemia type III 

    Romero Cortadellas, Lídia (Date of defense: 2023-09-22)

    Iron is a biometal involved in many physiological processes that are essential for life. Iron metabolism is a complex and tightly regulated process both at the systemic and cellular level. Proper iron homeostasis relies ...

    Control de la estabilidad de ciclinas de G1 por nutrientes 

    Hernández Ortega, Sara (Date of defense: 2014-07-18)

    El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En la fase G1 del ciclo ...

    CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development 

    Miralpeix Monclús, Cristina (Date of defense: 2019-12-04)

    Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, whereas sedentary ...

    CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation 

    Fosch Masllovet, Anna (Date of defense: 2022-07-28)

    Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the population with overweight has nearly tripled since 1975, and the tendency is still growing. These data have an impact on health and ...

    CPT1C-ABHD6 interaction in hypothalamic neurons: implications for bis (monoacylglycero) phosphate metabolism and the endolysosomal system 

    Reguera Moreno, Ana Cristina (Date of defense: 2023-12-04)

    El sistema endolisosomal juga un paper crític en la funció neuronal i ha emergit com a un potencial objectiu per al tractament de diverses malalties neuronals, com els trastorns neurodegeneratius i fins i tot l'obesitat. ...

    CPT1C-dependent regulation of GluA1 trafficking under metabolic stress 

    Casas Prat, María (Date of defense: 2019-11-18)

    Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still maintains the capacity ...

    La cronicidad en enfermedad mental: políticas y modelos de atención integrados y centrados en las personas y la comunidad 

    Amo Mora, Isabel (Date of defense: 2023-09-09)

    La creciente prevalencia de enfermedades mentales y cronicidad orgánica genera una comorbilidad con impacto en la salud, calidad de vida y eficiencia de los modelos de atención. Se necesita un enfoque multidisciplinario ...

    Desarrollo de nuevos métodos para el análisis del polifosfato en células humanas 

    Sarrias Giménez, Ana (Date of defense: 2023-07-19)

    Nombre / Nom / Name Ana Apellidos / Cognoms / Surname Sarrias Giménez Dirección de correo electrónico / Adreça de correu electrònic / email address (opcional / optional) anasargim@gmail.com Departamento / Departament ...

    Development of C75-CoA loaded polymeric micelles targeting brain CPT1A: A novel nanomedicine-based approach to fight obesity and cancer 

    García-Chica, Jesús (Date of defense: 2023-12-01)

    Brain lipid metabolism has a key role in many physiological processes, and its malfunction is associated with a plethora of diseases, such as obesity and glioblastoma multiforme (GBM). Carnitine palmitoyl transferase 1A ...

    Development of novel bioinks formulations based on supramolecular self-assembled hydrogels for tissue regeneration. 

    Merino Gómez, María (Date of defense: 2023-04-21)

    The field of tissue engineering relies on the use of biomaterials as scaffolds for tissue and organ regeneration. If properly designed, these scaffolds can mimic the in vivo microenvironment while also providing initial ...

    Development of sol-gel silica-based 3D printable materials with tunable degradation, mechanical properties and drug release capacity for tissue engineering 

    Rodríguez González, Raquel (Date of defense: 2023-02-07)

    The bone is a very complex organ that participates in multiple critical functions for the human body. Bone can be affected by different health issues, such as physical trauma or tumor, and the body cannot regenerate large ...

    El polifosfat és un element clau durant la replicació del DNA. 

    Bru Rullo, Samuel (Date of defense: 2015-07-20)

    Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large amount of phosphate ...

    Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama 

    Masip Sales, Núria (Date of defense: 2022-01-27)

    Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament amb la seva ...

    Evaluation of biomarkers for studying new challenges in tobacco control 

    Pérez - Martín, Hipólito (Date of defense: 2023-11-17)

    El tabaquismo es reconocido a nivel global como un factor de riesgo significativo para la salud pública y una de las principales causas de muertes prevenibles. España ha implementado políticas de control del tabaco con el ...

    Evaluation of the impact of Spanish smoking legislation on tobacco consumption and passive exposure 

    Lidón Moyano, Cristina (Date of defense: 2017-10-06)

    In Spain, two smoke-free laws have been passed after the approval of the FCTC. In 2005, it came into effect a smoke-free legislation (Law 28/2005). This law was a great advance for public health in Spain; however, it was ...