CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development 

    Miralpeix Monclús, Cristina (Date of defense: 2019-12-04)

    Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, whereas sedentary ...

    CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation 

    Fosch Masllovet, Anna (Date of defense: 2022-07-28)

    Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the population with overweight has nearly tripled since 1975, and the tendency is still growing. These data have an impact on health and ...

    CPT1C-ABHD6 interaction in hypothalamic neurons: implications for bis (monoacylglycero) phosphate metabolism and the endolysosomal system 

    Reguera Moreno, Ana Cristina (Date of defense: 2023-12-04)

    El sistema endolisosomal juga un paper crític en la funció neuronal i ha emergit com a un potencial objectiu per al tractament de diverses malalties neuronals, com els trastorns neurodegeneratius i fins i tot l'obesitat. ...

    CPT1C-dependent regulation of GluA1 trafficking under metabolic stress 

    Casas Prat, María (Date of defense: 2019-11-18)

    Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still maintains the capacity ...

    Development of C75-CoA loaded polymeric micelles targeting brain CPT1A: A novel nanomedicine-based approach to fight obesity and cancer 

    García-Chica, Jesús (Date of defense: 2023-12-01)

    Brain lipid metabolism has a key role in many physiological processes, and its malfunction is associated with a plethora of diseases, such as obesity and glioblastoma multiforme (GBM). Carnitine palmitoyl transferase 1A ...

    Papel de CPT1C en el desarrollo axonal y en el transporte de los endosomas tardíos 

    Palomo Guerrero, Marta (Date of defense: 2018-03-02)

    La paraplejía espástica hereditaria agrupa un conjunto de desórdenes neurodegenerativos caracterizados por espasticidad y rigidez muscular. Todos ellos están relacionados clínica y patológicamente con problemas en el ...