Now showing items 47-66 of 107

    Functional analysis of EXD2 in mitochondrial homeostasis 

    Faria da Silva, Joana Raquel (Date of defense: 2017-03-24)

    One of the most fundamental events in the history of life is the origin of mitochondria. It was firstly proposed by Ivan Wallin, and later popularized by Lynn Margulis, as part of the endosymbiotic theory, that mitochondria ...

    Genome-wide transposon analyses: annotation, movement and impact on plant function and evolution 

    Hénaff, Elizabeth Marie (Date of defense: 2013-06-20)

    The diversity of life forms around us is astounding: a walk in the woods, or even down the street, shows us organisms of different morphologies: two legs, four legs, wings; different capacity of interaction with our ...

    Glucosa 1,6-bisfosfat i glucosa 1,6-bisfosfat fosfatasa en el teixit muscular de mamífer 

    Bassols Teixidó, Anna (Date of defense: 1986-01-01)

    En el Departament de Bioquímica de la Facultat de Medicina s'està portant a terme, des de fa un temps, una línia d'investigació basada en l'estudi del metabolisme del 2,3-bisfosfoglicerat, el cofactor de la ...

    hAGT inhibitors as chemotherapy enhancers 

    Tintoré Gazulla, Maria (Date of defense: 2015-07-01)

    The O6-alkylguanine DNA alkyltransferase (hAGT or MGMT) is a DNA repair protein in charge of removing alkyl adducts from the O6 position of guanines, blocking their cytotoxic effects and playing an important role as a ...

    Hallmarks of Dermal Fibroblast Aging 

    Salzer, Marion Claudia (Date of defense: 2019-04-10)

    Aging is accompanied by cellular, extracellular and systemic changes that impair tissue function. Stromal alterations, such as degeneration of the extracellular matrix, are thought to contribute to organ deterioration in ...

    Human Immunodeficiency Virus infection, asymptomatic atherosclerosis, and inflammation: A candidate gene study 

    Ibáñez Lladó, Laura (Date of defense: 2014-04-07)

    Acquired Immunodeficiency Syndrome (AIDS) was identified more than 30 years ago. The challenges for the clinicians and Human Immunodeficiency Virus (HIV)-infected individuals have changed over the years. Nowadays, viral ...

    Identificació i estudi funcional de nous gens supressors tumorals implicats en càncer de pulmó 

    Bonastre Llort, Ester (Date of defense: 2014-10-30)

    El càncer de pulmó afecta 1,6 milions de persones a tot el món, i és la primera causa de mort per càncer. El promig de l’índex de supervivència als 5 anys per tots els càncers està al voltant del 50%, mentre que en el cas ...

    Identificación de posibles factores de Myzus persicae implicados en la transmisión del virus del grabado del tabaco (TEV) y estrategias para interferir su expresión 

    Urizarna España, María (Date of defense: 2013-04-26)

    En esta tesis se aborda la identificación de factores del pulgón Myzus persicae que podrían participar en el proceso de transmisión del potyvirus del grabado del tabaco, Tobacco etch virus (TEV), y se explora la posibilidad ...

    Identification of mechanisms of acquired resistance to taxanes in triple negative breast cancer using patient-derived xenografts: a step closer to clinics 

    Gómez Miragaya, Jorge (Date of defense: 2018-04-27)

    Chemotherapy is a general treatment for most breast tumors and depending on breast cancer subtype combination with targeted anti-hormonal or anti-HER2 therapy is conducted. Taxane-based regimens constitute the most common ...

    Identification of novel therapeutic targets and tumor suppressor genes in colon cancer using genome-wide high‐throughput approaches 

    Bazzocco, Sarah (Date of defense: 2016-01-27)

    Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes ...

    Implicación de LRP5 en la enfermedad cardiovascular 

    Romero Sandoval, July Carolina (Date of defense: 2014-12-01)

    Atherosclerosis is an inflammatory process characterized by the accumulation of lipids and fibrous elements in large arteries. It is the main underlying pathological process leading to heart attack and stroke. Low-densit ...

    Implicación del Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) en el remodelado vascular y cardiaco 

    Revuelta López, Elena (Date of defense: 2015-12-01)

    La dislipemia y la hipoxia tienen un impacto directo en el remodelado vascular y cardiaco. La isquemia cardiaca produce una disfunción generalizada del corazón caracterizada por alteraciones en el metabolismo celular y ...

    Insulators: estructura y funciones 

    Fresán Salvo, Ujué (Date of defense: 2016-05-11)

    Los insulators son complejos de DNA y proteínas, cuya función no solo consiste en impedir la comunicación enhancer-promotor y/o bloquear la expansión del silenciamiento de la heterocromatina como clásicamente se habían ...

    The Iron Regulatory Protein/Iron Responsive Element (IRP/IRE) system: functional studies of new target mRNAs and pathological implications for novel IRE mutations 

    Luscieti, Sara (Date of defense: 2016-11-22)

    Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of iron uptake, storage ...

    La proteína transportadora de retinol tipo 4 y el retinol en la resección hepática con isquemia y reperfusión 

    Elias Miró, Maria (Date of defense: 2014-01-24)

    La presente tesis se enmarca dentro del estudio de la lesión por isquemia-reperfusión (I/R), y sus efectos sobre la regeneración, en hígados esteatósicos y no esteatósicos. Uno de los principales riesgos en la cirugía ...

    Mechanisms behind the oncogene-induced senescence (OIS) – oncogene-induced apoptosis (OIA) decision in cells expressing p95HER2 

    Bernadó Morales, Cristina (Date of defense: 2015-04-23)

    In response to oncogenic stresses cells activate two different tumor suppressor mechanisms: Oncogene-induced senescence (OIS), a terminal cell proliferation arrest, or oncogene-induced apoptosis (OIA), which leads to cell ...

    Mejora de la eficiencia metastásica en un modelo de cáncer colorrectal humano y efecto del oncogén K-RAS en la transición de micro a macrometástasis 

    Álamo Vargas, Patricia (Date of defense: 2012-12-13)

    Los modelos de cáncer colorrectal (CCR) generados mediante inyección ortotópica de líneas celulares de CCR humano, cultivadas extensamente in vitro, tienen escasa eficiencia metastásica. Únicamente un porcentaje bajo de ...

    Microalgae as a new source of chitosans 

    Latil de Ros, Derek (Date of defense: 2017-03-07)

    Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the ...

    Modeling protein dynamics and protein-drug interactions with Monte Carlo based techniques 

    Hosseini, Seyed Ali (Date of defense: 2015-05-08)

    A complete understanding of complex formation between proteins and ligands, a crucial matter for pharmacology and, more in general, in biomedicine, requires a detailed knowledge of their static and dynamic atomic interactions. ...

    Molecular characterization of neurofibromatosis type 1–associated malignant peripheral nerve sheath tumours and functional identification of genes involved in their pathogenesis 

    Terribas Pérez, Ernest (Date of defense: 2016-01-20)

    Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...