Now showing items 62-81 of 107

    Mechanisms behind the oncogene-induced senescence (OIS) – oncogene-induced apoptosis (OIA) decision in cells expressing p95HER2 

    Bernadó Morales, Cristina (Date of defense: 2015-04-23)

    In response to oncogenic stresses cells activate two different tumor suppressor mechanisms: Oncogene-induced senescence (OIS), a terminal cell proliferation arrest, or oncogene-induced apoptosis (OIA), which leads to cell ...

    Mejora de la eficiencia metastásica en un modelo de cáncer colorrectal humano y efecto del oncogén K-RAS en la transición de micro a macrometástasis 

    Álamo Vargas, Patricia (Date of defense: 2012-12-13)

    Los modelos de cáncer colorrectal (CCR) generados mediante inyección ortotópica de líneas celulares de CCR humano, cultivadas extensamente in vitro, tienen escasa eficiencia metastásica. Únicamente un porcentaje bajo de ...

    Microalgae as a new source of chitosans 

    Latil de Ros, Derek (Date of defense: 2017-03-07)

    Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the ...

    Modeling protein dynamics and protein-drug interactions with Monte Carlo based techniques 

    Hosseini, Seyed Ali (Date of defense: 2015-05-08)

    A complete understanding of complex formation between proteins and ligands, a crucial matter for pharmacology and, more in general, in biomedicine, requires a detailed knowledge of their static and dynamic atomic interactions. ...

    Molecular characterization of neurofibromatosis type 1–associated malignant peripheral nerve sheath tumours and functional identification of genes involved in their pathogenesis 

    Terribas Pérez, Ernest (Date of defense: 2016-01-20)

    Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...

    Molecular mechanisms involved in the immunomodulation induced by LIF in cancer 

    Sala Hojman, Ada (Date of defense: 2016-07-15)

    LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...

    Molecular mechanisms of resistance to PI3K inhibitors 

    Castel Morales, Pau (Date of defense: 2016-05-09)

    The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...

    Molecular retention mechanisms of the G1 cyclin/Cdk complex in budding yeast 

    Abd El Rahim Metwally, Galal Yahya (Date of defense: 2016-01-13)

    Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...

    The Multiple Tasks Endured by PI3K during neural tube development 

    Torroba Balmori, Mª Blanca (Date of defense: 2016-11-11)

    Development of the spinal cord involves coordination between exposure to localized extracellular signals and controlled activation of intracellular signaling pathways. This way, neuroepithelial cells firstly proliferate ...

    Neovascularización mediada por factor tisular en la placa aterosclerótica 

    Espinosa Ferrer, Sonia (Date of defense: 2015-07-20)

    Las enfermedades cardiovasculares son la primera causa de muerte en todo el mundo y representan uno de los desafíos primordiales en la investigación biomédica. La aterosclerosis es causante de la mayoría de las enfermedades ...

    New insights into sphingolipid metabolism and functions by using chemical tools 

    Cingolani, Francesca (Date of defense: 2015-07-10)

    Sphingolipids (SLs), essential components of cell membranes, are bioactive molecules involved in the regulation of a variety of cellular processes. Ceramide and sphingosine generally mediate anti-proliferative stimuli, ...

    New strategies to reduce liver ischemia – reperfusion injury in fatty and non-fatty livers: a focus on sirtuin 1 implication 

    Pantazi, Eirini (Date of defense: 2015-07-06)

    Ischemia-reperfusion injury (IRI) is an inevitable situation in clinical settings such as liver transplantation and hepatic resection. It develops when blood flow is interrupted for a long period of time (ischemia) and ...

    New targets in tumor angiogenesis to block tumor re-growth and therapeutic resistance 

    Bassani, Nicklas (Date of defense: 2017-12-15)

    Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these agents mainly serve ...

    Novel molecular alterations in amyotrophic lateral sclerosis and frontotemporal lobar degeneration spectrum 

    Andrés Benito, Pol (Date of defense: 2019-12-17)

    Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle ...

    Novel roles for the mitotic kinase Nek7 in hippocampal neurons 

    Avó Freixo, Francisco Duque Projecto (Date of defense: 2016-10-20)

    The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such as their stability, ...

    Nuevos análogos conformacionalmente restringidos de la metoxamina 

    Delgado Cirilo, Antonio (Date of defense: 1986-01-01)

    Las modificaciones moleculares que constituyen el objetivo de la presente Tesis pretenden aportar nuevos datos que permitan un más amplio conocimiento de los requisitos estructurales y estereoquímicos necesarios tanto ...

    Nutrition and cardiometabolic risk: a prospective population-based cohort study 

    Funtikova, Anna N. (Date of defense: 2015-11-30)

    Cardiovascular diseases (CVD) are the principal cause of mortality worldwide. Lifestyle plays a crucial role in preventing the development of CVD, and one of its key elements is diet, which directly affects cardiometabolic ...

    El papel del AMPc, del estrés del retículo endoplasmático y de las adipocitoquinas en el trasplante hepático 

    Jiménez Castro, Mónica B. (Date of defense: 2014-03-04)

    In this thesis the role of cyclic AMP , the endoplasmic reticulum stress and adipocytokines such as adiponectin, resistin and visfatin injury in I/R in steatotic liver grafts and non- steatotic undergoing transplantation ...

    Papel del receptor low density lipoprotein receptor-related protein 1 (LRP1) en la isquemia y fisiopatología cardiovascular 

    Cal Pérez-Quevedo, Roi (Date of defense: 2013-04-19)

    Las alteraciones del metabolismo lipídico causadas por la isquemia miocárdica tienen profundos efectos en el estado fisiológico del corazón. En el corazón isquémico, la hipoxia incrementa la formación de vacuolas lipídicas ...

    Paper de SirT2 en el control epigenètic de la mitosi 

    Sima Teruel, Núria (Date of defense: 2016-06-30)

    La cromatina és una estructura nucleoproteica, dinàmica i jeràrquicament organitzada dins del nucli cel•Iular. La seva estructura, organització i funció està controlada al llarg del cicle cel.lular, per processos epigenètics ...