Now showing items 88-107 of 107

    Regulación epigenética de la expresión estriatal del receptor de adenosina A(2A) en enfermedades neurológicas con trastorno motor asociado 

    Villar Menéndez, Izaskun (Date of defense: 2014-06-06)

    La adenosina es un metabolito presente en todo el organismo con distintas funciones fisiológicas. En el sistema nervioso central, desempeña un importante papel como neuromodulador a través de la interacción con sus receptores ...

    Role of Histone Deacetylase HDAC7 in B Lymphocyte Biology 

    Román González, Lidia (Date of defense: 2014-01-31)

    Within the hematopoietic system, all mature blood cells are generated. Every differentiation step is characterized by the activation of a new, lineage specific, genetic program and the extinction of the previous one. To ...

    Role of p38 MAPK in breast cancer 

    Cánovas Bilbao, Begoña (Date of defense: 2017-07-20)

    In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival and proliferation. ...

    Role of SIRT6 in Chromatin 

    Santos Barriopedro, Irene (Date of defense: 2015-05-08)

    Chromatin compaction is regulated by different factors, among them histone posttranslational modifications. There are different histone modifications, and among them, acetylation and methylation of lysine residues. Acetylation ...

    Role of the sigma-1 receptor in the sensory-discriminative and affective-motivational components of acute and chronic pain 

    de la Puente Robles, Beatriz (Date of defense: 2015-12-18)

    The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...

    Selective blockade of the sigma-1 receptor for the treatment of pain of different aetiology: Preclinical studies 

    Gris Ormo, Georgia (Date of defense: 2015-12-04)

    The present Doctoral Thesis focuses on the study of the Sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...

    Síntesis de inhibidores de Atg4B y desarrollo de nuevos métodos de bioconjugación basados en derivados del ácido escuárico 

    Bilbao Girona, Ana (Date of defense: 2019-10-30)

    El modelo de negocio de I+D de las compañías farmacéuticas está en crisis desde hace décadas debido a los grandes costes y a la baja productividad. En consecuencia, la identificación de nuevos biomarcadores y el desarrollo ...

    Síntesis de los alcaloides indólicos ngouniensina y epingouniensina 

    Zulaica Gallego, Ester (Date of defense: 1988-01-01)

    Se describe la primera síntesis total de los alcaloides indólicos ngouniensina y epingouniensina. La síntesis se basa en la elaboración del sustituyente metileno exocíclico en una etapa posterior a la de construcción del ...

    Sobre las helmintofaunas de las especies de insectívoros y roedores del delta del Ebro (NE de la Península Ibérica) 

    Torres Martínez, Jordi (Date of defense: 1988-01-01)

    No cabe duda que ha sido sobretodo la peculiaridad de los biotopos deltaicos lo que ha propiciado el interés por el estudio de los helmintos parásitos de ciertos hospedadores del Delta del Ebro. Cabe advertir, por tanto, ...

    El soporte nutricional y las adipocitoquinas en parcial hepatectomía con oclusión vascular 

    Mendes Braz, Mariana (Date of defense: 2014-07-07)

    La esteatosis hepática es un factor de riesgo en PH bajo I/R, situación quirúrgica normalmente aplicada en la práctica clínica para reducir el sangrado asociado a las resecciones hepáticas. Teniendo en cuenta tal problemática ...

    Structural and functional studies on Escherichia coli alpha-2-macroglobulin: a snap- trap peptidase inhibitor 

    Garcia Ferrer, Irene (Date of defense: 2015-12-01)

    The balance between proteolytic and antiproteolytic activity is crucial in many biological processes such as nutrition, immune defence, virulence and tissue remodelling. Therefore, it is controlled by several mechanisms, ...

    Structural Insights into Substrate Binding and Regulation of E3 Ubiquitin Ligases in the Nedd4 Family using NMR Spectroscopy 

    Escobedo Pascual, Albert (Date of defense: 2014-11-06)

    Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels proteins for a variety ...

    Structural Modeling and Characterization of Protein Interactions of Biomedical Interest: The Challenge of Molecular Flexibility 

    Pallara, Chiara (Date of defense: 2016-02-04)

    Proteins are large biomolecules that play essential functional and structural roles within cells and that typically act through their interaction with other proteins and biomolecules, forming highly specific functional ...

    Structure, dynamics and interactions of the N-terminal domain of the androgen receptor 

    De Mol, Eva (Date of defense: 2014-06-26)

    Prostate cancer (PCa) is the second most common cancer in men after lung cancer. Around 1.1 million men worldwide were diagnosed with PCa in 2012. PCa depends essentially on androgen stimulation for growth and cell survival. ...

    Supramolecular Strategies to Control the Assembly of Organic-Based Materials 

    Riba Moliner, Marta (Date of defense: 2015-12-11)

    The focus of this thesis is the use of supramolecular chemistry to functionalize polymers to obtain organic-based materials with a control of their structure and properties. The non-covalent functionalization of polymers ...

    The epigenetic regulation of cell cycle and chromatin dynamic by sirtuins 

    Martínez Redondo, Paloma (Date of defense: 2014-06-25)

    The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded in the DNA. The ...

    The role of p19 C-H-Ras protein in metastasis and proliferative pathways 

    García Cruz, Roseli Marlen (Date of defense: 2013-10-03)

    H-Ras es un protooncogen que codifica para dos proteínas por splicing alternativo la p19 y la p21 (1,2). La p21 presenta mayor tamaño y se localiza en la membrana en donde realiza la función de GTPasa que activa múltiples ...

    The role of the Tousled Like Kinases in genome stability and mammalian development 

    González Burón, Helena (Date of defense: 2014-03-19)

    The human Tousled-like kinases 1 and 2 (TLKs) are predicted serine/threonine kinases that show maximal activity in S phase and are transiently inhibited by the DNA damage response (DDR). Both TLKs interact with and ...

    ToxT promoter recognition by ToxR transcription factor, a co-activator within the Vibrio cholerae virulence cascade 

    Pieretti, Simone (Date of defense: 2016-06-02)

    Cholera is an acute diarrheal infection caused by the bacterium Vibrio cholerae. An estimated 2.9 million of cases and about 100000 cholera deaths occur annually all over the world. Upon ingestion of the V. cholerae, the ...

    Using Phosphorodiamidate Morpholino Oligomers (PMOs) to characterize the role of neurofibromin in cell physiology 

    Biayna Rodríguez, Josep (Date of defense: 2016-01-22)

    The role of neurofibromin, the product of the Neurofibromatosis Type 1 (NF1) gene, in cell physiology is still not well understood. Considering the different traits associated to NF1 it is clear that neurofibromin participates ...