Mostrando ítems 19580-19599 de 42254
Llorente Lope, Alicia (Fecha de defensa: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Ertl, Iris Elisabeth (Fecha de defensa: 2015-02-20)
El complexos SWI/SNF són remodeladors de cromatina dependents d’ATP que es troben altament conservats al llarg de l’evolució. Aquests complexos poden regular l’accessibilitat a una zona genòmica alterant l’estat de la ...
Amo Maestro, Laura del (Fecha de defensa: 2021-06-11)
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and crystallization of three ...
Ibáñez Sabaté, Maria (Fecha de defensa: 2013-03-05)
The work developed during this PhD has embraced several topics that I divide in three blocks. Each block contains two chapters in this dissertation. Additionally, a general introduction of the different topics is provided ...
Campàs i Homs, Mònica (Fecha de defensa: 2002-10-17)
The goal of this thesis has been to design, characterise and optimise an electrochemical DNA sensor array. In order to investigate the oligonucleotide probe immobilisation and the hybridisation detection, preliminary ...
Teller Amado, Sara (Fecha de defensa: 2016-02-05)
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological ...
Ścigaj, Mateusz (Fecha de defensa: 2016-12-02)
La tesis aborda la integración monolítica de óxidos funcionales sobre silicio y la exploración de intercaras entre SrTiO3(110), SrTiO3(111) y otros óxidos En primer lugar la tesis detalla la integración monolítica del ...
Giné Garriga, Maria (Fecha de defensa: 2010-07-12)
En països desenvolupats, la característica demogràfica actual més rellevant és l'envelliment de la població. Tenint en compte el percentatge de gent gran i la tendència de la població en el futur, es considera essencial ...
Sentandreu Benavent, Maria (Fecha de defensa: 2013-01-18)
After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed ...
Martínez Serrano, Xavier (Fecha de defensa: 2020-02-26)
Fins ara, les aproximacions meta-òmiques utilitzen tecnologies de seqüenciació d'alt rendiment, que produeixen una quantitat enorme de dades, desafiant així els ordinadors moderns actuals. Hem desenvolupat una nova pipeline ...
Benítez i Porras, Francesc (Fecha de defensa: 2016-01-29)
Plasma Polymerization is a novel technique for the preparation of polymer-like thin film coatings at low temperatures onto almost any type of substrates: plastic, metal, semiconductors, wood, textile fibers or membranes, ...
Ma, Guofen (Fecha de defensa: 2014-10-03)
El sistema dopaminèrgic has estat molt estudiat en els darrers anys, principalment degut a la seva implicació en diverses patologies com la malaltia de Parkinson, la esquizofrènia o la síndrome de Tourette, així com també ...
Nikolakopoulou, Myrto-Georgia (Fecha de defensa: 2021-01-29)
Freshwater degradation has been largely attributed to excess nutrient concentrations of anthropogenic origin. Freshwater degradation in combination with water scarcity are the reason of severe stress on water resources ...
Cardó i Vila, Marina (Fecha de defensa: 2003-07-25)
Macrophages require presence of M-CSF to survive and proliferate. Incubation of bone marrow macrophages with soluble factors (LPS or IFN-gamma) or insoluble factors such as extracellular matrix proteins (Decorin, FN) ...
Rubio Patiño, Camila (Fecha de defensa: 2012-10-31)
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect is mediated by the GC ...
Polat, Ibrahim H. (Fecha de defensa: 2016-11-04)
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
Delgado Martin, Gonzalo (Fecha de defensa: 2014-07-14)
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...
Cervela Cardona, Luis Manuel (Fecha de defensa: 2019-11-21)
El reloj circadiano es un mecanismo celular endógeno capaz de medir el paso del tiempo y traducir las señales medioambientales, principalmente luz y temperatura, en respuestas temporales que resultan en ritmos metabólicos ...
Eibes González, Susana (Fecha de defensa: 2016-09-13)
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this process: cyclin- ...
Fernández Estévez, Ariadna (Fecha de defensa: 2016-11-25)
Diferentes funcionalidades pueden ser obtenidas en diversas superficies a través de topografía en lugar de química, inspirándose en la naturaleza. El principal objetivo de esta tesis es la investigación de la litografía ...