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Now showing items 29750-29769 of 43179
Molecular characterization of High Risk Neuroblastoma. Potential biomarkers for high-risk neuroblastoma classification
[eng] BACKGROUND: High-risk neuroblastoma (NB) represents a heterogeneous group of tumors, whereby patients can display response to treatment and long-term outcome or develop early progressive, chemoresistant disease with ...
Molecular characterization of microbial diversity in wastewater treatment and reuse
La generació d’aigua residual és una conseqüència inevitable de les activitats humanes. Aquestes activitats modifiquen les característiques de les aigües de consum, contaminant-les i invalidant la seva posterior aplicació ...
Molecular characterization of neurofibromatosis type 1–associated malignant peripheral nerve sheath tumours and functional identification of genes involved in their pathogenesis
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...
Molecular characterization of pluripotency in embryos and embryonic stem cells
Pluripotent cells are unique due to their developmental potential and the possibility to study them is the key step to understand human development. These cells are characterized by their ability to originate all the ...
Molecular Characterization of the circadian clock in Solanum lycopersicum
El rellotge circadià és un mecanisme molecular de mesura del temps que genera ritmes d'aproximadament 24 hores en el metabolisme i la fisiologia, en sincronització amb el cicle de dia i nit. Durant l'última dècada, la ...
Molecular characterization of the circadian function and the transcriptional regulatory network at the core of the pistil circadian clock
El rellotge circadià és un mecanisme cel·lular endogen que genera ritmes biològics amb un període de 24 hores. A les plantes, el sistema circadià regula molts processos essencials, inclosos, entre d'altres, el temps de ...
Molecular characterization of the microenvironment in CLL-like monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia
The analysis of the microenvironment in CLL-like monoclonal B cell lymphocytosis (MBL) and early-stage chronic lymphocytic leukemia (CLL) is relevant for understanding the natural history of CLL. To this end, a total of ...
Molecular characterization of the Ppz1 phosphatase and its regulatory subunit Hal3
La proteína Ser / Thr fosfatasa Ppz1 de S. cerevisiae es un componente importante en el mantenimiento de la homeostasis de cationes monovalentes (K+ y Na+) y, como tal, incide en múltiples procesos celulares, tales como ...
Molecular charaterization of Primary Ciliary Dyskinesia|
Introduction: Motile cilia are highly complex hair-like organelles protruding from the apical surface of epithelia cells of various human organ systems. They contain a 9+2 tubulin-based axoneme core structure and an ...
Molecular classification and biomarkers in hepatobiliary cancer
[spa] El cáncer hepatobiliar (incluye principalmente el carcinoma hepatocelular [HCC] y el cáncer del tracto biliar [BTC]) representa la tercera causa de muerte relacionada con cáncer en todo el mundo [1]. Menos de la mitad ...
Molecular complexity of the differential growth of freshwater diatom species along pH gradients
Aquesta tesi proporciona una visió general dels mecanismes moleculars que responen a una àmplia gamma de condicions de pH en espècies de diatomees d'aigua dolça filogenèticament diferents. Les diatomees són un grup divers ...
Molecular containers based on aryl-extended calix[4]Pyrroles
Aquesta Tesi s'ocupa del disseny i síntesi de receptors còncaus que posseeixen cavitats hidrofíliques: receptors covalents, caixes metàl·liques i càpsules no covalents. Per a la seva construcció, triem la bastida de ...
Molecular containers based on calix[4]pyrrole scaffolds
Aquesta tesi compren la síntesi i l'estudi de diferents contenidors moleculars basats en una estructura macrocíclica de calix[4]pirrol. Els contenidors moleculars poseeixen cavitats polars funcionalitzades ideals per al ...
Molecular contents and functional characterization of extracellular vesicles in plasma of Alzheimer’s disease patients: analysis in response to the AMBAR treatment
[eng] The hypothesis underlying the AMBAR study research seeks to evaluate the clinical efficacy of PE, in combination with albumin and intravenous immunoglobulin replacement (IVIG), as a treatment for Alzheimer's disease ...
Molecular design of bivalent ligands for GPCRs
Els GPCRs són proteïnes amb set dominis transmembrana amb la capacitat de produir una cascada de senyalització intracel·lular en resposta a una àmplia gamma de molècules, com ara hormones, neurotransmissors, ions, fotons, ...
Molecular details of prostaglandin synthesis catalyzed by cyclooxygenase-2 and its inhibition by aspirin
La ciclooxigenasa-2 (COX-2) és un enzim hemoproteic, bifuncional, homodiméric associat a la membrana, el qual catalitza l’oxigenació de diversos PUFAs. La COX-2 és un dels dos principals enzims humans responsables dels ...
Molecular determinants of human oocyte quality in assisted reproduction
Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of these couples will ...
Molecular determinants of the Kv1.3/KCNE4 interaction
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
Molecular determinants of TRPV4 channel regulation
TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this ...
