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Now showing items 11138-11157 of 41733
Drug design at biological systems level
The explosion of reductionist approaches at the end of the XXth century allowed for fast and high-throughput data collection in pharmaceutical industry, but did not deliver the expected gain in drug discovery performance. ...
Drug development and immunological characterization of Acinetovax, a prophylactic vaccine against resistant nosocomial bacteria Acinetobacter baumannii
Aquesta tesi industrial tenia com a objectiu transferir la vacuna Acinetovax duna companyia biotecnològica a una companyia farmacèutica on pogués ser industrialitzada. Aquesta vacuna va ser desenvolupada per prevenir les ...
Drug Discovery Targeted to Transthyretin Related Amyloidosis
Several drug discovery approaches has been performed to find new compounds able to interact with high affinity with the hormone binding site of the homotetrameric protein transthyretin (TTR), and stabilize this tetramer, ...
Drug discovery with a FRET Biosensor of scaffolding interactions in the N-terminal region of c-Src = Descubrimiento de fármacos mediante un biosensor basado en FRET sensible a las interacciones en la región N-terminal de c-Src
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...
Drug repurposing of bioenergetic modulators: use in treatment and vaccination of protozoan parasitic diseases
Las leishmaniasis, la tripanosomiasis Americana y Africana, y la malaria son enfermedades parasitarias que constituyen un importante problema de salud global que afecta mayoritariamente a países en desarrollo. El aumento ...
Drugs of abuse in the aquatic and atmospheric compartments: analysis, occurrence, and assessment of human cosumption in Spain
In the last decades, the development of increasingly sensitive analytical techniques has revealed the presence in the environment of a large number of potentially dangerous compounds for human health and the environment, ...
Drying process intensification by using freezing pretreatments and ultrasound application at high and low temperature
[eng] Drying process is commonly used to reduce fruits and vegetables moisture content in order to enlarge their shelf life. However, convective drying can promote product quality parameters losses due to thermal and air ...
DSGEs and PVARs: applications to macroeconomics
This thesis adopts DSGE and PVAR models to examine three questions in macroeconomics. The first chapter singles out some pitfalls that DSGE models face when a fraction of rule-of-thumb consumers is assumed in order to ...
DSP-based CW lidars for clouds and aerosol
This thesis aims at exploring the limits of low peak-power, low-cost, all-semiconductor, compact lidars (laser radars) for range-resolved remote sensing of atmospheric aerosols and clouds. The systems investigated are based ...
Du musée colonial au musée des diversités. Intégrations et effets du multiculturalisme sur les musées ethnologiques
En politique rien ne semble possible sans références culturelles, sans la mobilisation d’un imaginaire collectif. Avec la déclaration de nombreux Etats de leur caractère multiculturel au cours de la seconde ...
Dual effect of Semaphorin 4D blockade in neuroendocrine tumor malignization: from vessels to macrophages
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its therapeutic targeting ...
Dual function of Notch signaling and role of Hes/Hey genes in the inner ear sensory development
Durante el desarrollo del oído interno, Notch presenta dos modos de funcionamiento: inducción lateral, que se asocia con la especificación prosensorial, e inhibición lateral, asociada a la determinación de las células ...
Dual inhibition of KIF11 and the Androgen Receptor axis as a novel therapeutic approach for Castration Resistant Prostate Cancer
El càncer de pròstata és la segona neoplàsia més freqüent i la cinquena causa de mortalitat per càncer en homes. El 2020 es van diagnosticar al voltant de 1.4 milions de nous casos i va donar lloc a més de 375.000 morts a ...
Dual regulatory role of Polycomblike-3 (PCL3/PHF19) in prostate cancer
Polycomblike proteins (PCLs) have been shown to regulate Polycomb Repressive Complex 2 (PRC2) by enhancing its catalytic activity and guiding PRC2 to its target genes in embryonic stem cells. However, little is known about ...
Dual role of CDK5 on cognitive deficits and striatal vulnerability in Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, which are associated ...
Dual role of matrix metalloproteinases in brain injury and neurorepair after cerebral ischemia
L'ictus isquèmic és una de les principals causes de mortalitat, discapacitat de llarg termini i de morbiditat al món. Actualment, els únics tractaments eficaços són el tractament trombolític intravenós amb activador del ...
Dual Transition Metal/Photoredox Catalysis for the Synthesis of Quaternary Carbon Stereocenters
Els estereocentres de carboni quaternaris són omnipresents en molècules bioactives i farmacèuticament rellevants. No obstant això, la construcció d'enllaços C-C que condueixen a carbonis quaternaris quirals segueix sent ...
Dual-curing thiol-acrylate-epoxy thermosets for functional applications
Avui en dia, cada vegada més aplicacions exigeixen materials amb un disseny complex, missió complicada en polímers termoestables, i per això el curat dual és una eina extremament útil en el disseny de termoestables. El ...
Dual-tracer molecular neuroimaging : methodological improvements and biomedical applications
Positron emission tomography (PET) is a functional imaging method that allows studying physiological, biochemical or pharmacological processes in vivo. PET is being used in both research and clinical practice. In the brain, ...
El dualisme natura/cultura en ecologia. Anàlisi del pensament ecològic margalefià i de les pràctiques de les cooperatives de consum ecològic
Ens trobem en una crisi ecològica entesa en el sentit més ampli. Oîkos com a llar: crisi econòmica, política, alimentària, ambiental, social… La interpretació del planeta en situació de crisi ecològica resulta del ...
