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The Role of cross-modal semantic interactions in real-world visuo-spatial attention
In our everyday life we must effectively orient attention to relevant objects and events in multisensory environments. The impact of cross-modal links for attention orienting to spatial and temporal cues has been widely ...
The Role of cyclin O in the DNA damage response
Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in the DNA what activate ...
Role of cytoplasmic cyclin D1 in radial migration of cortical neurons during brain development
Ciclina D1 pot interaccionar amb CDK4/6 per promoure el pas de la fase G1 a S en el cicle cel·lular. Recentment, s'ha descobert que cèl·lules cancerígenes sobreexpressen Ciclina D1 per al creixement tumoral, però també ...
Role of D-fagomine and omega-3 plyunsaturated fatty acids on gut microbia and related metabolic changes in healthy rats and in a model of fat-induced prediabetes
Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...
Role of DOR/TP53INP2 in the control of muscle protein degradation = Papel de DOR/TP53INP2 en el control de la degradación de proteínas en el músculo esquelético
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
Role of DPPA3 in hypoxia and tumour dormancy in cancer
Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...
Role of DYRK1A in hippocampal neuroplasticity : implications for Down syndrome
Synaptic connections in the brain respond throughout their lives to the activity of incoming neurons, adjusting their biological properties to increment activity-dependent changes. Hippocampal neuronal plasticity disruptions ...
Role of DYRK1A in the development of the cerebral cortex : Implication in Down Syndrome
In this work we have assessed the possible contribution of the human chromosome-21 gene DYRK1A in the developmental cortical alterations associated with Down Syndrome using the mBACTgDyrk1a mouse, which carries 3 copies ...
Role of early postnatal nutrition during lactation in offspring metabolic health programming
Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...
Role of EPHA3 in colorectal cancer
Los receptores EPH (receptores de efrina) constituyen la subfamilia más grande de los receptores tirosina quinasas en mamífero. Se unen a las efrinas, ancladas a las membranas celulares mediante un enlace glicosilfosfati ...
Role of EphB receptors in intestinal epithelial cell positioning and colorectal cancer progression
In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin ...
Role of epigenetic modifications in acute promyelocytic leukemia
Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...
The role of FGF21 in the metabolic response to amino acid restriction
Obesity and associated metabolic diseases have reached epidemic proportions, affecting not only high-income countries but also low- and middle-income ones. In this context, the search for therapeutic approaches to treat ...
Role of flavonoids in the modulation of intestinal alterations associated with metabolic challenges: obesity and aging
La prevalença de l'obesitat i l'envelliment s'han incrementat dràsticament en les últimes dècades. L'obesitat s'associa a una pèrdua de la funció de barrera intestinal i a canvis en la microbiota (disbiosis). Això provoca ...
The role of Friday sermon in shaping the opinion of the worshippers in Jordan
This field study investigates the intricate relationship between Friday sermon (khutba) and the worshippers' public opinion in Jordan. Prompted by the taboo label assigned to scholarship on khutba, it probes whether the ...
Role of Fsp27 in lípid homeostasis during nutrient deprivation
This Thesis has been divided into three different chapters, the regulation of Fsp27 during the fasting adaptation, the transcriptional regulation of Fsp27 in liver and finally the role of FSP27 as a lipid-droplet protein ...
Role of Galectin-1 in pancreatic cancer stroma, a small but mischievous protein with a novel nuclear function
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, ...
Role of gaseous neurotransmitters in the effects and expression of opioid and cannabinoid receptors during neuropathic pain
El dolor neuropàtic es causat per una lesió o malaltia del sistema nerviós somatosensiorial, i es caracteritza per la presencia d'alodínia e hiperalgèsia. Actualment el seu tractament es basa en la teràpia amb opioids, ...
Role of Guanylate Cyclase Activating Proteins in photoreceptor cells of the retina in health and disease
In the last two decades, it has been done a thoroughly research about the role of Guanylate Cyclase Activating Proteins (GCAPs) in photoreceptor cells of the retina as activity regulators of Retinal Guanylate Cyclase ...
Role of gut commensal microbiota regulating colonic sensory-related systems
La microbiota comensal del intestino se considera un factor clave en la homeostasis gastrointestinal. Las alteraciones funcionales gastrointestinales (síndrome del intestino irritable, SII) y las enfermedades inflamatorias ...
