Browsing Universitat de Barcelona by Title

Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes

Fernández Carasa, Irene (Date of defense: 2021-06-29)

Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of ...

Investigating the role of testis-mitochondiral genes in Drosophila lethal (3) malignant brain tumor

Louzao Boado, Ánxela (Date of defense: 2019-04-30)

Genetically tractable models such as Drosophila melanogaster may help to identify new approaches to halt malignant growth. During my doctoral thesis, I performed a screen to find mitochondrial genes required for the growth ...

Investigating the Signs and Sounds of Cypro-Minoan

Valério, Miguel Filipe Grandão (Date of defense: 2016-04-08)

The aim of this dissertation is to advance our knowledge of Cypro-Minoan, a group of undeciphered syllabic inscriptions dated roughly to the 16th or 15th through the 11th centuries BCE and found mostly on Cyprus, with small ...

Investigation of branched and linear polymers as oral delivery systems of antimalarial drugs

Martí Coma-Cros, Elisabet (Date of defense: 2019-09-27)

Malaria is an infectious disease that affects nearly half of the population in 90 countries around the world. In 2017 it was estimated that there were 219 million cases and 435,000 deaths disproportionately distributed ...

Investigation of the phospholipid peripheral region of lactose permease in model membranes

Suárez Germà, Carme (Date of defense: 2013-11-07)

The interaction between a membrane protein and its surrounding phospholipids is thought to be crucial for the correct folding and function of the protein. This thesis is focused on the investigation of the interplay between ...

Investigation on force detection methods for optical trapping and sensing inside living cells

Mas Soler, Josep (Date of defense: 2017-01-09)

Optical Tweezers (OT) are a light-based non-invasive tool that has played an important role during the last decades in the field of biophotonics, together with the advances in optical microscopy techniques. Optical trapping ...

Investigations in animal models of anti-NMDAR encephalitis

García Serra, Anna (Date of defense: 2021-09-14)

[eng] BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuronal antibody-mediated disease that associates with prominent neuropsychiatric symptoms and predominantly affects women of childbearing ...

Investigations into the role of translations in abstract algebraic logic

Moraschini, Tommaso (Date of defense: 2016-06-08)

This memoir is divided into two parts, devoted to two topics in (ab-stract) algebraic logic. In the first part we develop a hierarchy in which propositional logics “L” are classified according to the definability conditions ...

Invisible structures = Estructures invisibles

Milne, Joanne Leonie (Date of defense: 2016-01-14)

This thesis is an investigation into the visualization of cosmological propositions associated with string theory. Research into the work of contemporary theoretical physics led to the question, how does one visualize what ...

Involvement of Alternative Splicing Regulation in Adipose Tissue Thermogenic Induction

Castellá Giner, Moisés (Date of defense: 2023-09-29)

[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism is tightly regulated ...

Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease

Rodríguez Urgellés, Ened (Date of defense: 2022-01-20)

Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...

Involvement of photoinhibition and redox balance in acclimation and developmental processes of plants

Muñoz Roldán, Paula (Date of defense: 2020-04-24)

Environmental constraints and developmental processes in plants can lead to light energy excess in chloroplasts by lowering the threshold at which light becomes saturating by a lack of electron acceptors in the light-processing ...

Involvement of Polyamines in PAMP-triggered Immunity and Systemic Acquired Resistance (SAR). Extragenic Suppressors of Immune Hybrid Incompatibility

Liu, Changxin (Date of defense: 2020-10-29)

The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered immunity in autoimmune ...

Involvement of Polyamines in Ribosome Biogenesis and Identification of Potential Genes Associated with Spermine Resistance in Arabidopsis thaliana

Murillo Villuendas, Ester (Date of defense: 2023-10-20)

[eng] Polyamines are small polycationic molecules that contain amino groups and are found in all living organisms. This study is aimed at acquiring a comprehensive understanding of the diverse roles of polyamines in plants, ...

Involvement of the Microtubule-Regulated RhoGEF GEF-H1 in the G12 family signaling pathways

Garrido Antequera, Georgina (Date of defense: 2014-09-16)

Heterotrimeric G proteins are masters regulators of cell homeostasis. They coordinate the signaling between G protein coupled receptors (GPCRs) and their intracellular effectors. Heterotrimeric G proteins are composed of ...

Ion beam synthesis of silicon-carbon structures and related materials

Calvo Barrio, Lorenzo (Date of defense: 1999-07-16)

The goal of this dissertation is the study and characterisation of high dose Carbon (C) implantation processes into Silicon (Si) and related materials for the synthesis of Silicon Carbide (SiC). The attainment of ...

iPSCs, CRISPR/Cas9 y protocolos de diferenciación basados en factores de transcripción para generar nuevos modelos neuronales y astrocíticos del síndrome de Sanfilippo

Benetó Gandia, Noelia (Date of defense: 2020-07-16)

El objetivo general de esta tesis doctoral ha sido la generación de nuevos modelos celulares para el síndrome de Sanfilippo y su utilización para ensayar una aproximación terapéutica para esta enfermedad basada en el uso ...