Guardiola Bagán, Salvador (Date of defense: 2017-09-15)
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed ...
Borilović, Ivana (Date of defense: 2018-11-23)
Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of ...
Díaz Torres, Raúl (Date of defense: 2018-07-20)
Nanoscience and Nanotechnology have become research areas that promote the design and fabrication of novel devices with a number of different applications with the aim of satisfying the growing demand ...
Gomes, Paula Alexandra de Carvalho (Date of defense: 2000-11-23)
A fast and direct surface plasmon resonance (SPR) method for the kinetic analysis of the interactions between peptide antigens and immobilised monoclonal antibodies (mAb) has been established. Protocols ...
Gallen Ortiz, Albert (Date of defense: 2019-02-01)
The Thesis deals with the preparation, coordination chemistry and use in asymmetric homogeneous catalysis of several optically pure P-stereogenic ligands containing a tert-butylmethylphosphino fragment. In ...
Puig Gomà-Camps, Eduard (Date of defense: 2019-06-20)
Alzheimer’s disease (AD) is the most common form of dementia. It was first described in 1906 by Alois Alzheimer. Later on, in 1984 George Glenner and Colin Masters isolated the amyloid-beta (Aβ) peptide ...
Castellanos Ortega, Sonia (Date of defense: 2010-05-07)
Molecular electronics is an emergent area of the new technologies related to the use of organic and biological materials in optoelectronic and electronic devices. Among the materials used in electronic ...
Fuster Juncà, Cristina (Date of defense: 2019-06-14)
The research work presented in this thesis aims to understand the transport mechanism of two described BBB-shuttles, THRre and MiniAp-4. To achieve these objectives, different techniques have been used ...
Frigolé Vivas, Marta (Date of defense: 2020-09-23)
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to ...
Matarín Morales, Joan Antoni (Date of defense: 2021-12-15)
Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles ...