Potrony Mateu, Míriam (Date of defense: 2018-09-28)
Melanoma is the malignant tumor arising from melanocytes and is the most aggressive of the common skin cancers. Melanoma is the tumor with the highest heritability (58%) and around 10% of cases occur ...
Pineda Moncusí, Marta (Date of defense: 2020-12-16)
Aromatase inhibitors (AI) are one of the main therapies to treat estrogen-receptor positive breast cancer. AI use is associated with several side effects that affects patient’s quality of life and reduces ...
Moles Fernández, Alejandro (Date of defense: 2022-01-31)
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision ...
Aguirre Gómez, Josu (Date of defense: 2020-07-14)
The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from ...
Mazuelas Gallego, Helena (Date of defense: 2021-01-28)
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the ...
Delgado Serrano, Luisa Fernanda (Date of defense: 2021-12-02)
Human cancer arises as a result of genomic alterations that transform cells and make them to grow without control and to pathological levels. The characterization of such genomic changes has enabled ...
González Rosado, Santiago (Date of defense: 2016-04-28)
The genetic and molecular bases of most of the human diseases have become one of the main goals of the human biology in the last decades. To be able to unveil the genetic variations and the affected ...
Valls Margarit, Jordi (Date of defense: 2021-06-08)
One of the central aims of biology and biomedicine has been the characterisation and understanding of genetic variation across humans, to answer important evolutionary questions and to explain phenotypic ...
Díaz Gay, Marcos (Date of defense: 2019-11-25)
Colorectal cancer (CRC) is one of the malignant neoplasms with higher incidence and mortality in Spain, Europe and worldwide. As a complex disease, both environmental and genetic factors influence CRC ...
Esquerdo Barragan, Mariona (Date of defense: 2017-05-26)
Protein post-translational modifications are regulatory mechanisms that cells use in response to intra- and extracellular signals. These signals modulate a panoply of conjugating enzymes that modify ...