Privat Contreras, Cristian (Date of defense: 2023-04-20)
[eng] Intrinsically disordered proteins (IDPs) landed on the molecular biology framework at the turn of the 20th century to challenge the established protein function- structure paradigm. Due to their ...
Dumaze, Anaëlle (Date of defense: 2023-11-08)
[eng] My thesis was part of a collaborative project at the interface of neuropharmacology and medicinal chemistry that aimed to better understand the neuromodulation mechanisms associated with Alzheimer’s ...
González Álamos, María (Date of defense: 2023-11-21)
[eng] The vault particle, with a mass of 10 MDa and dimensions of 70 nm x 40 nm x 40 nm, is the largest ribonucleoprotein described in the eukaryotic kingdom. The vault shell is organized in two identical ...
Iannizzotto, Flavia (Date of defense: 2023-12-01)
[eng] MYC dysregulation is the most common alteration in cancers, driving several cellular processes that cooperatively promote aberrant cell growth and proliferation. Among them, the induction of protein ...
Guercetti, Julian (Date of defense: 2023-10-25)
[eng] The current doctoral thesis titled “Microarray Strategies for Multiplexed Immunochemical Analysis” was carried out in the context of two research projects, expecting to develop multiplexed ...
Murillo Villuendas, Ester (Date of defense: 2023-10-20)
[eng] Polyamines are small polycationic molecules that contain amino groups and are found in all living organisms. This study is aimed at acquiring a comprehensive understanding of the diverse roles of ...
Piticchio, Serena (Date of defense: 2021-05-11)
Efficient discovery of bioactive molecules is an essential goal of Computer-Aided Drug Design (CADD). The molecules can be used as chemical probes, to validate novel targets, or as starting points for ...
Camps i Fajol, Cristina (Date of defense: 2022-12-19)
[eng] Cancer is the second leading cause of death globally. The gold standard for cancer has historically been surgery, radiotherapy and chemotherapy. Although the efficacy of chemotherapy has been ...