Garcia Castaño, Albert (Date of defense: 2017-07-11)
Most of the current in vitro cell culture models do not reproduce the anatomy of tissues and physiological behavior of cells in vivo and provide misleading results when compared to the real tissue. ...
Valls Margarit, Maria (Date of defense: 2017-07-07)
Ischemic heart disease is a major cause of human death worldwide owing to the heart minimal ability to repair following injury. Other than heart transplantation, there are currently no effective or ...
Oberhansl, Sabine (Date of defense: 2012-10-29)
The present thesis entitled “Construction of versatile biomolecule nano-platforms via Dip-pen Nanolithography and their application in bio-sensing and cell differentiation” aims at contributing to the ...
Rodríguez Seguí, Santiago Andrés (Date of defense: 2010-01-15)
[spa] El desarrollo de microambientales artificiales ordenados en un formato de microarray (microarrays celulares, también conocidos en inglés como "cellular microarrays") se ha propuesto como una ...
Altay, Gizem (Date of defense: 2018-12-20)
Intestinal epithelium is highly specialized tissue organized into crypt-villus units relevant for their effective barrier function and nutrient absorption. In the crypt units reside the proliferative ...
Hortigüela Lázaro, Verónica (Date of defense: 2017-06-30)
Cells in tissues are exposed to extracellular signals that integrate and appropriately translate into specific responses. Receptors at the cell membrane recognize a variety of soluble ligands, extracellular ...
Diéguez Moure, Lorena (Date of defense: 2012-07-27)
Biosensors are nowadays a powerful tool to enable the detection of specific biological interactions and to evaluate the concentration dependence in the response. A biosensor usually consists of three ...
Larrañaga Carricajo, Enara (Date of defense: 2021-05-25)
Intestinal cells self-organize into 3-dimensional (3D) organoids that recapitulate the in vivo structural and functional characteristics when embedded in a 3D cell-derived protein mixture (Matrigel). ...
Vila Giraut, Anna (Date of defense: 2020-12-10)
Conventional in vitro cell culture models do not possess the complexity that the native tissues offer. Because of this, the functional properties of the tissues are not properly mimicked, which causes ...
Abad i Lázaro, Aina (Date of defense: 2023-07-20)
[eng] The standard in vitro model of the small intestine in the field of drug development still consists in a monolayer of cancer-derived cells seeded on a hard substrate. Despite the huge advances ...