Universitat Pompeu Fabra
Ara mostrant els elements 2185-2204 de 3215
In these days of significant changes and the rapid evolution of technology, the amount of datascience has to deal with the growth incredibly fast, and the size of data could be prohibitive.Multiple Sequence Alignments (MSA) ...
Animal models are crucial to improve the knowledge of the mechanisms underlying the different pathological processes. These models are also excellent tools to facilitate the research of new targets for the treatment of ...
The breakthrough in the technological field has allowed the extraction of large amounts of the so-called omics data. The analysis and Integration of this type of data by means of advanced statistical and bioinformatics ...
The rapid increase of obesity has encouraged the study of the aetiology of eating disorders. Besides genetic, social and metabolic factors, obesity is caused by over-eating and has high rate of relapse to abnormal food-taking ...
Unequal dosage of X-linked genes between males (XY) and females (XX) is balanced by dosage compensation mechanisms. In Drosophila melanogaster, the dosage compensation complex specifically induces a 2-fold hypertranscription ...
One of the major challenges in electronic literature is the search for literariness in the works. This topic is still largely debated among scholars due to the diverse representations that the literary can acquire and the ...
Classical planning is the problem of nding a sequence of actions that take an agent from an initial state to a desired goal situation, assuming deter- ministic outcomes for actions and perfect information. Satis cing ...
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-‐differentiated epithelial cells to convert to motile mesenchymal cells. EMT is critical f ...
Human genome project published their first human whole genome sequence on 2001 at the cost of billions of dollars. Since, the cost of sequencing is decreasing faster than Moore’s law. Now, we not only have sequenced thousands ...
Oxidation of histone H3 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) is important in triple-negative breast cancer (TNBC) cells to generate compacted heterochromatin regions. However, the molecular mechanisms by which it ...
Cytoplasmic polyadenylation binding proteins (CPEB) are a family of RNA binding proteins which control the translation of its target mRNAs by modulating the length poly(A) mRNA tail. Cytoplasmic polyadenylation was originally ...
Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to stress by expanding ...
To address one of the most fascinating questions in the history of life, the origin of animal multicellularity, we needed experimentally tractable representatives from each of the unicellular lineages, that are relative ...
At the end of G1 phase, cells have to decide between continue proliferation or remain in a quiescent state (G0). This decision point, known as “Start” in yeast and “Restriction Point” in metazoans, marks irreversibly the ...
Snail1 is the master regulator of the Epithelial-to-Mesenchymal Transition (EMT) and is also crucial for fibroblast activation upon TGFβ signaling. In cancer, Snail1 expression in primary tumors correlates with the appearance ...
El paradigma clàssic on un medicament interacciona amb un únic target biològic vinculat a una malaltia es posa en dubte. Actualment es reconeix que un medicament interacciona amb múltiples targets biològics i que aquests ...
The next Wi-Fi generation poses in front of a massive challenge as the main enabler for new services and applications. Traffic requirements are expected to keep rising year over year, challenging Wi-Fi networks to cope ...
What is the nexus between EU external migration policies and the democratization of Southern Mediterranean countries (SMCs)? Although being two essential components of EU external action and central elements within ...
In this PhD I have used NGS technologies in different organisms and scenarios such as in ENCODE, comparing the conservation and evolution of long non-coding RNA sequences between human and mouse, using experimental evidences ...
The CHRNA5/A3/B4 genomic cluster encodes for the alpha5, alpha3 and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs). Human genetic studies have revealed a significant association of variants in this ...
