Bergadà Martínez, Araceli (Date of defense: 2024-03-08)
Cognition is a physiological brain function that refers to the process of acquiring and managing knowledge and understanding. It embraces multiple domains, including memory. Intellectual disability ...
López Polo, Vanessa (Date of defense: 2024-03-07)
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the ...
Kopańska, Karolina (Date of defense: 2024-02-29)
The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory decisions regarding chemical safety. The general objective of this thesis is to identify gaps ...
Condemi, Livia (Date of defense: 2024-03-07)
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex ...
Ivancic, Dimitrie (Date of defense: 2024-04-03)
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome ...
Özer, Ege Ekin (Date of defense: 2024-03-21)
In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. ...
Shekari, Mahnaz (Date of defense: 2024-04-03)
This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the ...
Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Delgado Tejedor, Anna (Date of defense: 2024-03-21)
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. ...
Morales Pastor, Adrián (Date of defense: 2024-04-11)
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation ...