Plass Pórtulas, Mireya (Date of defense: 2011-07-12)
L’splicing és el mecanisme pel qual els introns són eliminats del pre-mRNA per generar un trànscrit madur. Aquest procés és dut a terme per un complex macromolecular anomenat spliceosoma i requereix el ...
Pich Roselló, Oriol (Date of defense: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Bonforti, Adriano (Date of defense: 2022-07-27)
L'aparició de la pluricel·lularitat (MC) va definir un esdeveniment evolutiu important en la història de la vida al nostre planeta. Ha tingut lloc diverses vegades dins de grups independents i diferents ...
López Valenzuela, María (Date of defense: 2015-01-15)
MicroRNAs (miRNAs) are major contributors to phenotypic diversity and have a demonstrated role in evolution. We performed an analysis on how miRNA nucleotide substitutions may have contributed to human ...
Heredia Genestar, José María (Date of defense: 2020-01-28)
La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva ...
Renom, Pere (Date of defense: 2023-02-22)
According to estimates, over the 3.5 billion years that have elapsed since the appearance of life, the Earth has been inhabited by some 4 billion different species, of which 99.99% have already become ...
Elek, Anamaria (Date of defense: 2024-04-19)
Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal ...
Piñero, Jordi (Date of defense: 2023-05-08)
This thesis aims at establishing the basis for a statistical physics theory of major evolutionary transitions. Its structure is based on three major pillars: nonequilibrium thermodynamics and information ...