Ferrando Martorell, Eva (Date of defense: 2015-11-10)
The activation of Notch1 receptor triggers differential outcomes depending on the upstream activating ligand. This way, Jag1-Notch1 activation promotes endothelial to hematopoietic transition process ...
Colomer Montañà, Carlota (Date of defense: 2017-12-21)
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly ...
Galán i Palma, Luis (Date of defense: 2023-03-22)
Pluripotent stem cells (PSCs) have the ability to self-renew and give rise to almost every somatic cell type. Because of their enormous potential as a tool for regenerative medicine, understanding ...
Sinha, Roshani (Date of defense: 2016-12-16)
Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. ...
Guiu Sagarra, Jordi (Date of defense: 2012-11-26)
La regió de l’aorta-gonada-mesonefros (AGM) és el primer nínxol de les cèl·lules mare hematopoètiques. Està descrit que la via de Notch és necessària per generar artèries i cèl·lules mare hematopoètiques. ...
D'Altri, Teresa (Date of defense: 2013-07-26)
Margalef González, Pol (Date of defense: 2014-02-17)
L’IKKα nuclear regula la transcripció gènica i ha estat relacionada amb la progressió del càncer i la metàstasis, tot i que la connexió mecanística no s’entén massa bé. Hem ...
López Arribillaga, Erika (Date of defense: 2016-06-17)
Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally ...