Mostrando ítems 1-10 de 16
Rodríguez Galindo, Miguel (Fecha de defensa: 2023-11-13)
Tumor progression is dominated by two evolutionary forces: first mutagenesis, which provides the heritable variability where, secondly, natural selection acts. The main challenge of cancer genomics is ...
Hoffmann, Tobias (Fecha de defensa: 2021-04-08)
The splicing regulatory protein RBM10 is frequently mutated in bladder carcinomas. Analysis of RNA sequencing data of 476 bladder tumours (UROMOL) identified 469 alternative splicing (AS) events ...
Rodríguez Sodupe, Pau (Fecha de defensa: 2022-03-09)
The profiling of circulating-tumor DNA (ctDNA) in blood plasma, often known as liquid biopsy, has recently been of great interest in cancer research. This minimally-invasive strategy relies on the fact ...
Elosua-Bayés, Marc (Fecha de defensa: 2023-06-08)
Understanding multicellular organisms depends on the advent of technologies capable of delivering unprecedented levels of resolution. With new technologies come novel data modalities, which require ...
Caballero de la Torre, María (Fecha de defensa: 2021-09-09)
Retinoblastoma protein (RB) is a negative regulator of the cell cycle. In response to environmental stress, p38 MAPK phosphorylates RB in the N-terminal region, increasing the affinity of RB for E2F, ...
Cornet Bartolomé, Carles (Fecha de defensa: 2020-01-17)
High drug attrition rate during clinical and post market phases is one of the major factors contributing to the pharmaceutical industry productivity crisis. This problem is especially worrisome in the ...
Pich Roselló, Oriol (Fecha de defensa: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Vali Pour Jamnani, Mischan (Fecha de defensa: 2022-06-02)
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences ...
Abad Cortel, Etna (Fecha de defensa: 2023-12-13)
El conegut supressor tumoral p53 regula un ampli programa transcripcional que protegeix envers el càncer. No obstant, la complexitat d’aquest programa fa difícil determinar el rol de cada gen regulat ...
Heredia Genestar, José María (Fecha de defensa: 2020-01-28)
La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva ...