Villegas Mirón, Pablo (Date of defense: 2021-07-19)
The evolutionary history of the human genome has been shaped by the selection of multiple elements in response to different environmental pressures. The analysis of regulatory adaptations and the ...
Sampietro Bergua, Mª Lourdes (Date of defense: 2007-01-19)
In this thesis we have addressed three different although related topics. First, we studied the post-mortem mutation damage rate of contaminated DNA sequences in ancient human remains focusing on the ...
Dobón Berenguer, Begoña (Date of defense: 2018-11-23)
The evolution of the genome is driven, among other factors, by the composition of the genome, the functional output of the gene products, and by environmental pressures. Among the environmental factors, ...
Nye, Jessica (Date of defense: 2018-12-17)
Although universal and unavoidable, aging does not occur in a uniform way. In this dissertation, we assessed the effects of early life exposure to pro-inflammatory risk factors (air pollution and obesity) ...
Sikora, Martin (Date of defense: 2010-06-04)
Una de les forces selectives més fortes que han afectat a les poblacions humanes en la història més recent és el paràsit de la malària: Plasmodium falciparum, que és la causa de varis exemples d'adaptació ...
Walsh Capdevila, Sandra (Date of defense: 2019-12-18)
Africa is the origin source of modern humans. Despite that African populations harbor the highest levels of genetic diversity worldwide, they remain underrepresented in genetic studies. Therefore, in ...
Invergo, Brandon M. (Date of defense: 2013-11-22)
Phototransduction is the biochemical process by which a light stimulus is converted to a neuronal signal. The process functions through complex interactions between many proteins, which work in concert ...
Dall'Olio, Giovanni Marco (Date of defense: 2013-10-28)
In this thesis we developed two approaches to study positive selection and genetic adaptation in the human genome. Both approaches are based on applications of network theory. In the first approach, ...