Di Stefano, Bruno (Date of defense: 2014-06-05)
One of the major goals of current stem cell research is understanding the mechanism of somatic cell reprogramming by Oct4, Sox2, Klf4 and Myc (OSKM) into induced pluripotent stem cells (iPSCs). However, ...
Galán i Palma, Luis (Date of defense: 2023-03-22)
Pluripotent stem cells (PSCs) have the ability to self-renew and give rise to almost every somatic cell type. Because of their enormous potential as a tool for regenerative medicine, understanding ...
Santanach Buxaderas, Alexandra (Date of defense: 2016-10-28)
Polycomb group (PcG) proteins are transcriptional repressors that control cell identity and development. In mammals, at least five different Cbx prorteins are believed to associate with the core Polycomb ...
Pedone, Elisa (Date of defense: 2014-12-16)
Mouse embryonic stem (ES) cells derived from the inner cell mass of the blastocyst can be maintained in culture, under pluripotent conditions, using Serum+LIF medium. However, it has been published that ...
Sottile, Francesco (Date of defense: 2017-01-18)
Homotypic and heterotypic cell-cell fusion are key processes during development and tissue regeneration. On the other hand, aberrant heterotypic cell fusion between cancer and normal cells can contribute ...
Sebastián Perez, Rubén (Date of defense: 2021-09-10)
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C ...
Alcaine Colet, Anna (Date of defense: 2019-11-04)
The self-renewing nature of embryonic stem cells (ESCs) is a consequence of their ability to proliferate while maintaining pluripotency, by means the capacity to differentiate into all adult cell types. ...