Arroyo Sánchez, Rodrigo (Date of defense: 2014-06-20)
Network and systems biology disciplines could revolutionize the study of complex diseases by taking proteins back to their context, considering a much broader perspective of their environment without ...
Tur Torres, Juan (Date of defense: 2017-03-22)
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability ...
Maíllo Carbajo, Carlos (Date of defense: 2016-06-21)
The Cytoplasmic Polyadenylation Element Binding (CPEB)-family of RNA-binding proteins is composed of four paralogs in mammals, CPEB1-4. The CPEBs control the translation of the targeted mRNAs by modulating ...
Cuesta Borràs, Estefania (Date of defense: 2019-11-28)
Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. ...
Ezquerra González, Artur (Date of defense: 2019-06-27)
Microtubules (MTs) mediate a range of essential cellular processes including cell division, intracellular transport and organelle positioning, by forming specifically adapted arrays. Assembly, maintenance ...
Capdevila Busquets, Eva (Date of defense: 2016-03-17)
Breast cancer is a very heterogeneous disease with a poor prognostic outcome, largely due to its resistance to current cancer therapies. The balance between cell proliferation and apoptosis plays a ...
Romero Durana, Miguel Alfonso (Date of defense: 2018-11-26)
Proteins play a crucial role in virtually every biological process taking place within our cells. Most of the times, proteins do not participate in these processes alone but forming complexes of two or ...
Candotti, Michela (Date of defense: 2016-12-09)
This work aims to analytically understand the impact of two diametric opposite environments on protein structure and dynamics and compared them to the most common solvent on earth: water. The first ...
Sammito, Massimo Domenico (Date of defense: 2015-06-22)
ARCIMBOLDO is an ab initio phasing method for macromolecular crystallographic X-ray diffraction data, which combines location of model fragments such as polyalanine α- helices with the program PHASER ...
Sfriso, Pedro (Date of defense: 2016-03-18)
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded ...