Balmori de la Puente, Alfonso (Date of defense: 2020-10-23)
Phylogenetic and phylogeographic methods allow studying the evolutionary relationships between populations and species, patterns of genetic structure, and historical events that have modelled the current ...
Iacobucci, Simona (Date of defense: 2021-03-18)
Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural ...
Guberović, Iva (Date of defense: 2021-10-01)
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins ...
Blanco Ameijeiras, Jose Manuel (Date of defense: 2023-03-24)
[eng] The Central nervous system (CNS) originates from the coordinated events that result into neural specification and the morphogenic events that shape the neural tube (NT). Then, the embryonic NT ...
Vicioso Mantis, Marta (Date of defense: 2022-09-27)
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene ...
Santos Tapia, Celia (Date of defense: 2019-10-30)
Aneuploidy, defined as a chromosome number that deviates from a multiple of the haploid set, is a common feature in human cancer, and around 70% of human solid tumours are aneuploid. The resulting ...
Fernández Torras, Adrià (Date of defense: 2022-11-28)
[eng] In the quest for understanding complex biological systems, the scientific community has been delving into protein, chemical and disease biology, populating biomedical databases with a wealth of ...
Planas Fèlix, Mercè (Date of defense: 2020-10-05)
The identification and analysis of genomic variation across individuals has been central in biology, first through comparative genomics to answer evolutionary questions, and then in the context of ...
Soy Platero, Judit (Date of defense: 2014-07-17)
Arabidopsis thaliana seedling growth and development is influenced by both external (such as light and temperature) and internal (like hormones or circadian clock) factors. In short-day (SD) growing ...
Valdivieso Muñoz, Alejandro (Date of defense: 2020-03-05)
In many organisms, sex is determined by a combination of genetic and environmental influences. Epigenetic regulatory mechanisms such as DNA methylation integrate both types of influences. However, ...