Iruela Martin, Guillermo (Date of defense: 2021-09-16)
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack ...
Torres Yeste, Pol (Date of defense: 2022-12-20)
[eng] Visible-light photocatalysis is currently one of the hottest research areas in organic chemistry, due to the possibility that offers to form C-C and C-Het bonds in a green, non-toxic and efficient ...
Velasquez Benites, Juan Diego (Date of defense: 2022-07-14)
The structure and stability of molecules, the formation of supramolecular aggregates in the solid state or in solution and, therefore, many chemical and biological processes in which they participate ...
Pérez Palau, Marina (Date of defense: 2022-07-08)
This thesis consists in the development of a new methodology of α-alkylation of carbonyl compounds and its application to the synthesis of small molecules with therapeutic interest. In this context, the ...
Kennington, Stuart (Date of defense: 2020-12-21)
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the ...
Mir Morro, Bartomeu (Date of defense: 2019-11-22)
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology ...
Rojo Solé, Josep Maria (Date of defense: 2022-11-02)
[eng] P-Stereogenic ligands have demonstrated to be highly efficient for asymmetric catalysis, especially in metal-catalyzed asymmetric hydrogenation reactions. Among them, those bearing bulky substituents ...
Rovira Vidal, Anna (Date of defense: 2023-03-03)
[eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to ...
Lázaro Palacios, Ariadna (Date of defense: 2023-05-05)
[eng] This Doctoral Thesis is focused on the synthesis of cyclometallated platinum compounds with different structural modifications rationally designed specifically for biological or optical applications. ...