Fábrega Fernández, María José (Date of defense: 2018-01-12)
Gut microbiota play a critical role in maintaining human intestinal homeostasis and host health. Bacterial extracellular vesicles are key players in bacteria-host communication as they allow delivery ...
Fàbrega Ferrer, Montserrat (Date of defense: 2017-09-28)
The Escherichia coli infecting T7 bacteriophage shares a common dsDNA packaging mechanism with other bacteriophages of the Caudovirales order, Herpesviruses and Adenoviruses. The packaging machinery ...
Mir Bonnín, Joan Francesc (Date of defense: 2016-07-11)
Previous studies have reported the importance of carnitine palmitoyltransferase (CPT) 1A as an essential part of downstream ghrelin signaling in the central nervous system (CNS) for the control of food ...
Almacellas i Canals, Eugènia (Date of defense: 2018-11-21)
Lysosomes are the primary degradative organelles in mammalian cells. Indeed, lysosome enzymatic cocktail allows the degradation of a vast repertoire of cellular material through different converging ...
Diaz Garrido, Natalia (Date of defense: 2021-11-17)
The gut microbiota establishes dynamic and complex interactions with the intestinal epithelium and the immune system. In this regard, commensal microbiota plays essential role in the development and ...
Wu, Yuanbing (Date of defense: 2023-04-28)
[eng] Eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA) are omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) known to prevent atherosclerosis, stroke, obesity, ...
Martínez Delgado, Paula (Date of defense: 2018-10-11)
Mitosis is a process that ensure the correct distribution of the chromosomes between the two newly generated cells, is tightly regulated by two main processes, protein degradation controlled by the APC ...
Jiménez Félix, Alejandro (Date of defense: 2021-01-11)
This thesis is centered on the study of PolyPurine Reverse Hoogsteen (PPRH) hairpins technology as a tool for both gene silencing and gene editing. PolyPurine Reverse Hoogsteen (PPRH) hairpins are ...
Bayod Giron, Carles (Date of defense: 2021-05-07)
The nuclear receptors (NR) modulate gene transcription in a ligand-dependent manner throughout different mechanisms. A set of NR, including PPARγ and LXR, are important regulators of carbohydrate and ...
Aubets Gil, Eva (Date of defense: 2021-09-19)
This work is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as a gene silencing tool, and on the search of alternative methods for their delivery, including viral and non-viral ...