Loeck, Maximilian (Date of defense: 2022-09-16)
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised ...
Alvarez Periel, Elena (Date of defense: 2018-07-06)
Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, ...
Morales Paytuví, Frederic (Date of defense: 2022-02-04)
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During ...
Feu i Coll, Sònia (Date of defense: 2019-03-28)
This thesis investigates the mechanisms that are activated in response to replication stress induced with hydroxyurea, an agent that causes deoxyribonucleotides depletion and arrest cells in S phase, ...
Suelves Caballol, Núria (Date of defense: 2018-07-23)
Huntington’s disease (HD) is a rare genetic disorder caused by an aberrant expansion of a CAG trinucleotide in the huntingtin gene (Htt). The neuropathology of the disease is characterized by progressive ...
López Guimet, Júlia (Date of defense: 2018-04-25)
The aorta is the main artery of the body, whose function is to collect the blood ejected by the heart and distribute it to all tissues. The elastic degree of the aortic wall necessary to withstand blood ...
Romero Moya, Damià (Date of defense: 2017-01-16)
Homeostasis of the hematopoietic stem/progenitor cell pool relies on a finely tuned balance between self-renewal, differentiation and proliferation. Recent work has revealed the importance of mitochondria ...
Duch Gili, Paula (Date of defense: 2022-03-14)
Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression ...