Now showing items 21-40 of 92
Pi i Boleda, Berta (Date of defense: 2019-12-18)
INTRODUCCIÓ: Aquesta tesi doctoral està inclosa dins del Pla de Doctorats Industrials de la Generalitat de Catalunya i s’ha realitzat conjuntament entre la Universitat de Barcelona i una empresa veterinària privada: ...
Ruiz Xivillé, Núria (Date of defense: 2019-10-07)
El metilfenidat HCl (MPH) és un fàrmac clàssic per al tractament del TDAH en nens a partir dels 6 anys, quan altres mesures resulten insuficients. Aquest trastorn es manifesta principalment durant la infància i l’adolescència ...
El Moussaoui El Masnaoui, Salima (Date of defense: 2022-10-26)
[eng] Pain and inflammation are the most common and recurrent side effects after surgery and, understandably, the patient's most feared, affecting treatment adherence. The present work aims to characterize in vitro, ex ...
Vilaplana Saiz, Marta (Date of defense: 2021-01-22)
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in ...
Alqahtani, Abdulateef (Date of defense: 2023-10-25)
[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...
González Díez, Aleix (Date of defense: 2023-07-24)
[eng] G protein-coupled-receptors (GPCRs) are the largest family of membrane proteins and mediate important cellular responses. Metabotropic glutamate receptors (mGlu) belong to the Glutamate family/Class C GPCR. These ...
Cañellas Santos, Mariona (Date of defense: 2022-11-03)
[eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization of a pharmaceutical ...
Sortino, Rosalba (Date of defense: 2023-10-18)
[eng] G protein-coupled receptors (GPCRs) modulate diverse cellular responses to the majority of neurotransmitters and hormones within the human body. They exhibit much structural and functional diversity and are responsive ...
Gomila Juaneda, Alexandre (Date of defense: 2021-09-20)
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve that aim, the thesis ...
Laveriano Santos, Emily Pilar (Date of defense: 2022-11-29)
[eng] The rising of cardiometabolic risk factors like obesity, higher blood pressure, and alteration in the metabolism of lipids and glucose during adolescence increase the risk of type 2 diabetes mellitus and cardiovascular ...
Cano Fernández, Amanda (Date of defense: 2018-11-09)
Las enfermedades del sistema nervioso central (SNC) engloban a un conjunto de patologías de elevada gravedad debido a la importancia de este sistema para el organismo. La Epilepsia del Lóbulo Temporal (TLE) y la Enfermedad ...
Grau Valls, Laura (Date of defense: 2017-07-24)
Aquesta tesis doctoral està enfocada a la investigació de nous agents amb potencial activitat antitumoral, mitjançant la inhibició d'enzims claus per al desenvolupament i la progressió del càncer, com per exemple KRAS. De ...
Creus i Cuadros, Anna (Date of defense: 2018-02-27)
The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three quarters of CVD deaths ...
Novak, Ana (Date of defense: 2019-06-26)
Parenteral nutrition-associated liver dysfunction (PNALD) is one of the most severe long-term parenteral nutrition complications, which was attributed to the phytosterols, found in vegetable oil based lipid emulsions (LE). ...
Gil Girbau, Mª Montserrat (Date of defense: 2020-01-14)
La no iniciación ocurre cuando se le prescribe un nuevo tratamiento farmacológico a un paciente y este, toma la decisión de no empezarlo. La prevalencia de no iniciación oscila entre el 6% y el 28% en atención primaria y ...
Aznar Lou, Ignacio (Date of defense: 2017-06-29)
La no iniciación es un comportamiento que se caracteriza por no empezar aquellos tratamientos farmacológicos prescritos por primera vez. Este comportamiento puede estar influenciado por distintos factores y parámetros ...
Bujaldon Ormaechea, Esther (Date of defense: 2019-10-04)
La hepatectomía parcial bajo isquemia-reperfusión (PH + I/R) es una estrategia que se utiliza comúnmente en la práctica clínica para reducir la hemorragia durante la resección del parénquima hepático. Más del 20% de los ...
Busquets Figueras, Oriol (Date of defense: 2019-12-20)
Molts estudis previs sobre el paper de les cinases c-JUN N-terminal (JNK) no tenien en compte les diferències existents en l’activitat de cadascuna de les isoformes. Això va provocar que les propostes terapèutiques que ...
Aparicio Pelegrin, Rosa M. (Date of defense: 2021-04-15)
Els materials porosos polimèrics, també denominats escumes sòlides, són materials sòlids de baixa densitat i elevat volum de porus. Són ben coneguts per la seva varietat d’aplicacions i constitueixen una part integral de ...
Mallandrich Miret, Mireia (Date of defense: 2017-09-27)
En los últimos años, la investigación farmacéutica se ha centrado en mejorar el efecto de terapias actuales desarrollando nuevas formas farmacéuticas o vías de administración. Las rutas de administración transdérmica y ...