Izquierdo Villalba, Ismael (Date of defense: 2020-01-17)
G proteins transduce a myriad of signals from receptors at the plasma membrane. Recent reports point to a novel localization of G proteins at the mitochondria and other endomembranes where they regulate ...
Topal, Busra (Date of defense: 2020-01-08)
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative ...
Zagmutt Caroca, Sebastián (Date of defense: 2020-11-09)
Food intake and whole-body energy balance are regulated by the brain through a sophisticated neuronal network located mostly in the hypothalamus. In particular, the hypothalamic arcuate nucleus (ARC) ...
Rodríguez Escribà, Marta (Date of defense: 2020-01-21)
Transfer RNAs (tRNAs) are key adaptor molecules that mediate decoding of messenger RNAs (mRNAs) into proteins by complementary pairing of their anticodons with mRNA codons. tRNAs that undergo adenosine ...
Izquierdo García, Eduardo (Date of defense: 2020-09-14)
Sphingolipids (SLs) are one of the major classes of lipids in eukaryotes. In addition to being essential structural components of cell membranes, SLs also play capital roles as signalling molecules. ...
Villca Pozo, Faviola (Date of defense: 2020-09-16)
Los aromas se definen como productos no destinados al consumo como tales, que se añaden a los alimentos o a ciertos medicamentos para darles un olor o un sabor, o para enmascarar y/o modificar su olor ...
Riera Armengol, Pau (Date of defense: 2020-09-23)
El càncer colorectal (CCR) és una neoplàsia molt freqüent que causa una elevada mortalitat arreu del món. Els fàrmacs més utilitzats en el seu maneig són quimioteràpics (fluoropirimidines, oxaliplatí i ...
Bargalló, Manel Enric (Date of defense: 2020-07-31)
[spa] De entre las vacunas de ácidos nucleicos, las basadas en ARNm autoreplicativos (replicones) o ARNm convencionales unidos a diferentes nanopartículas (NPs) como: oro (Au-NP), nanocápsulas (NCs), ...
Ramírez Pedraza, Marta (Date of defense: 2020-12-18)
El carcinoma hepatocel·lular (HCC) és la segona causa de mort relacionada amb càncer i té avui en dia opcions terapèutiques molt limitades. Tot i que el HCC s’acostuma a estudiar en estats de malaltia ...
Raimondi, Giulia (Date of defense: 2020-06-08)
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of ...