Pedrola Teixell, Marina (Date of defense: 2022-07-14)
In the context of facilitated methodologies for the obtention of bioactive compounds, in this thesis we have explored the possibility of introducing reliable, pot-economic and semi-synthetic approaches ...
Cristóbal Valero, Helena (Date of defense: 2022-06-08)
La familia TAM consta de tres receptores de membrana de tipo tirosina-quinasa: TYRO3, AXL, MERTK. Sus ligandos son Growth Arrest-Specific 6 (GAS6) y la Proteína S (PROS1). Éstas últimas son proteínas ...
Hernández Madrigal, Miguel (Date of defense: 2022-06-17)
Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and ...
Revilla Sancho, Lluís (Date of defense: 2022-06-14)
INTRODUCTION: Inflammatory bowel disease is a complex intestinal disease with several genetic and environmental factors that can influence its course. The ethiology and pathophysiology of the disease ...
Jora, Beatrice Elena (Date of defense: 2022-10-27)
[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are ...
Cañellas Santos, Mariona (Date of defense: 2022-11-03)
[eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization ...
Ibeas Martínez, Kevin (Date of defense: 2022-11-04)
[eng] Food intake and energy homeostasis are tightly regulated by the brain through a complex neuronal network located in the hypothalamus. Within this region, the mediobasal hypothalamus (MBH) acts as ...
Bouzón Arnáiz, Inés (Date of defense: 2022-11-11)
[eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is ...
Lewis, Michael (Date of defense: 2022-11-11)
[eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different ...
Coll Iglesias, Laura (Date of defense: 2022-11-23)
[eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported ...