Szulc, Elizbieta Maria (Date of defense: 2020-01-09)
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured ...
Burciaga Monge, Alma Delia (Date of defense: 2020-01-31)
Los esteroles son una familia de compuestos triterpénicos que se presentan en forma libre o conjugada, como ésteres, glicósidos y acilglicósidos de esteroles. Cada especie vegetal tiene su propio perfil ...
Rosell Oliveras, Mireia (Date of defense: 2020-12-21)
The study of the 3D structural details of protein interactions is essential to understand biomolecular functions at the molecular level. In this context, the limited availability of experimental structures ...
García Lema, Jorge (Date of defense: 2020-10-08)
Adenosine deaminase acting on tRNAs (ADAT) is a eukaryotic heterodimer, composed by ADAT2 and ADAT3, that catalyses the deamination of adenosine-to-inosine in the anticodon loop of tRNAs. ADAT proteins ...
Izquierdo Villalba, Ismael (Date of defense: 2020-01-17)
G proteins transduce a myriad of signals from receptors at the plasma membrane. Recent reports point to a novel localization of G proteins at the mitochondria and other endomembranes where they regulate ...
Topal, Busra (Date of defense: 2020-01-08)
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative ...
Rodríguez Escribà, Marta (Date of defense: 2020-01-21)
Transfer RNAs (tRNAs) are key adaptor molecules that mediate decoding of messenger RNAs (mRNAs) into proteins by complementary pairing of their anticodons with mRNA codons. tRNAs that undergo adenosine ...
Ramírez Pedraza, Marta (Date of defense: 2020-12-18)
El carcinoma hepatocel·lular (HCC) és la segona causa de mort relacionada amb càncer i té avui en dia opcions terapèutiques molt limitades. Tot i que el HCC s’acostuma a estudiar en estats de malaltia ...
Raimondi, Giulia (Date of defense: 2020-06-08)
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of ...
Garrido Charles, Aida (Date of defense: 2020-01-15)
Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of ...