Szulc, Elizbieta Maria (Date of defense: 2020-01-09)
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured ...
Nicolàs i Aragó, Adrià (Date of defense: 2022-12-14)
[eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., ...
González Velasco, Lorena (Date of defense: 2021-09-14)
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α ...
Gutiérrez Fernández, Sara (Date of defense: 2018-04-26)
La plasticitat sinàptica és la capacitat que té el sistema nerviós de canviar la seva estructura i funcionament al llarg del desenvolupament. En processos d’aprenentatge, es formen noves espines ...
Moizé Arcone, Violeta (Date of defense: 2017-09-14)
BACKGROUND: Bariatric surgery (BS) is the most effective long-term therapy for the treatment of severe obesity. Benefits of BS include a reduction of overall and cardiovascular mortality, incidence of ...
Quintana Agustí, Mireia (Date of defense: 2019-09-30)
This thesis addresses three different subjects closely related. First, a phenotypic screening measuring cytotoxicity in the gastric cancer cell line HGC-27 is reported. Next, a targeted-based assay ...
Baumann, Adrian (Date of defense: 2018-11-22)
Endocytosis and endosomal trafficking are of central meaning in all eukaryotic cells. It enables cells to rapidly modify their surface exposure of signalling complexes, nutrient and ion transporters, ...
Palau de Miguel, Anna (Date of defense: 2016-11-30)
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) ...
Jiménez Panizo, Alba (Date of defense: 2021-12-14)
El receptor de glucocorticoides (GR) es un factor de transcripción que se expresa de forma ubicua y controla procesos esenciales para la vida como el metabolismo, la inflamación y la homeostasis. Aunque ...
Ramírez Pedraza, Marta (Date of defense: 2020-12-18)
El carcinoma hepatocel·lular (HCC) és la segona causa de mort relacionada amb càncer i té avui en dia opcions terapèutiques molt limitades. Tot i que el HCC s’acostuma a estudiar en estats de malaltia ...