Mostrando ítems 90-109 de 116
Vizcaya Molina, Elena (Fecha de defensa: 2018-12-19)
One of the most important questions in regenerative biology is how and when genes change expression to trigger regeneration programs. Resetting of gene expression patterns during injury responses is shaped by the coordinated ...
Sánchez Bellver, Laura (Fecha de defensa: 2023-12-15)
[eng] Ciliopathies encompass a broad group of heterogeneous inherited disorders associated with dysfunction of the cilium, a ubiquitous microtubule-based organelle that translates extracellular stimuli into cellular ...
López Aladid, Rubén (Fecha de defensa: 2022-10-20)
[spa] El pulmón siempre se ha considerado estéril. Sin embargo, el campo de la microbiota pulmonar se ha visto revolucionado por el avance de las técnicas moleculares. Cada individuo tiene un perfil de microbiota único, ...
Rosselló Xamena, Maria (Fecha de defensa: 2021-12-10)
El manteniment de l’homeòstasi en organismes adults és cabdal per la continuïtat dels individus; desregulacions d’aquest equilibri porten a l’aparició de malalties. La planària és un model d’estudi en regeneració i remodelació ...
Tell Martí, Gemma (Fecha de defensa: 2018-05-07)
El gen MC1R (codi OMIM: #155555) codifica pel receptor de la melanocortina 1 (MC1R) que s’expressa majoritàriament a la membrana dels melanòcits i està implicat en la regulació de la síntesi de melanina. El gen MC1R és ...
Ribó Gené, Sílvia (Fecha de defensa: 2017-12-01)
Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...
Sousa, Nidia de (Fecha de defensa: 2017-07-17)
A successful cell renewal, which occurs throughout the life of an organism, relies on multiple events, including proliferation and differentiation of progenitor cell populations, and death of unnecessary cells. Out of the ...
Pappa, Stella (Fecha de defensa: 2019-04-10)
During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...
Gheitasi, Hoda (Fecha de defensa: 2024-01-26)
[eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...
Pi Roig, Aina (Fecha de defensa: 2018-04-06)
Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb malformations. In zebrafish, ...
Martínez-Gil, Núria (Fecha de defensa: 2021-03-12)
Osteoporosis is a complex disease characterized by low bone mass, microarchitectural deterioration, and increased fracture risk. It is the most common bone disease that affects more than 200 million people worldwide and ...
Barbanti, Anna (Fecha de defensa: 2021-09-23)
Conservation actions aim to preserve and recover animal and plant species using in-situ or ex- situ strategies. The first, aims to protect and sustain populations in their natural habitat, the second are implemented when ...
Murcia Rosero, Lada (Fecha de defensa: 2019-10-28)
Most human solid tumors present signs of genomic instability. Activated oncogenes have been proposed to induce genomic instability through the generation of replicative stress. In this thesis, we have sown that the expression ...
Martínez Puchol, Sandra (Fecha de defensa: 2021-02-18)
L’objectiu principal de la present tesi doctoral ha estat l’optimització i aplicació de procediments basats en la seqüenciació massiva per a la descripció del viroma associat a l’aigua residual i a altres mostres d’interès ...
Castellarnau Serra, Montserrat de (Fecha de defensa: 2018-09-20)
El virus de l’hepatitis A (HAV), el prototip del gènere Hepatovirus, té una sèrie de característiques que el diferencien de la resta de membres de la família Picornaviridae. Entre aquestes, la via de sortida descrita ...
Castellano Escuder, Pol (Fecha de defensa: 2021-09-08)
This thesis is the product of three and a half years working on the complex world of metabolomics and nutrition. All the work presented here is focussed on the problems arising from associating and integrating ...
Garcia Gerique, Laura (Fecha de defensa: 2020-12-23)
Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...
Pascual Alonso, Ainhoa (Fecha de defensa: 2023-07-14)
[eng] MECP2 is a multifunctional gene involved in multiple processes such as transcription regulation, chromatin remodelling, splicing and miRNA regulation. Malfunction of MECP2 due to loss of function mutations leads to ...
Aguirre Gómez, Josu (Fecha de defensa: 2020-07-14)
The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...
Abad Morales, Víctor (Fecha de defensa: 2017-02-03)
La sumoïlació és una modificació posttraduccional (PTM) que consisteix en la conjugació covalent i reversible d’una proteïna SUMO (Small ubiquitin-like modifier) al residu lisina d’una proteïna diana. Igual que la ubiquitina, ...