Vilarrasa Blasi, Roser (Date of defense: 2020-10-09)
[eng] Nuclear organization and its impact on gene regulation have started to be elucidated thanks to the development of chromosomal conformation capture techniques. In this doctoral thesis, in situ Hi-C ...
Lorenzo Sanz, Laura (Date of defense: 2021-07-14)
[spa] La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a ...
Sidiropoulou, Zacharoula (Date of defense: 2021-09-17)
[eng] Breast cancer epidemiological patterns vary in European countries, presenting different incidence rates (49-148 new cases per 100,000 women) with a narrow but still variable range of mortality ...
Boldú Nebot, Laura (Date of defense: 2021-07-23)
[eng] Clinical pathologists have learned to identify morphological qualitative features to characterise the different normal cells, as well as the abnormal cell types whose presence in peripheral blood ...
Herranz Itúrbide, Macarena (Date of defense: 2021-09-23)
[spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones ...
Cucarull Martínez, Blanca (Date of defense: 2021-11-25)
[eng] Hepatocellular carcinoma (HCC) is the most common liver cancer and currently the fourth cause of cancer-related death. Since its appearance, the multityrosine kinase inhibitor (MKI) sorafenib has ...
Prieto Durán, Iván (Date of defense: 2022-09-16)
[spa] A día de hoy, el cáncer es la segunda causa de mortalidad en el ser humano y la mayoría de las muertes son producidas por la metástasis. Aunque se han postulado varias hipótesis para explicar ...
Montal Roura, Robert (Date of defense: 2020-10-07)
[spa] El cáncer hepatobiliar (incluye principalmente el carcinoma hepatocelular [HCC] y el cáncer del tracto biliar [BTC]) representa la tercera causa de muerte relacionada con cáncer en todo el mundo ...
Perramón Corominas, Meritxell (Date of defense: 2022-10-17)
[eng] Chronic liver diseases are one of the most prevalent diseases worldwide. The study of the signaling pathways involved in the fibrogenic process as well as the evaluation of novel therapies such ...
Moreno Cabrera, José Marcos (Date of defense: 2021-06-17)
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a ...