Mostrando ítems 1-10 de 29
Martínez Campanario, María del Carmen (Fecha de defensa: 2021-05-27)
Macrophages polarization from an inflammatory to a tolerogenic state occurs in both physiological and pathological, and this reprogramming is key in the development of several diseases as different as ...
Riera-Punet, Nina (Fecha de defensa: 2019-03-01)
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive degeneration of the lower (LMN) and upper motor neurons (UMN) in the spinal cord and brain, ...
Casulleras i Oliver, Mireia (Fecha de defensa: 2022-07-15)
[eng] This doctoral thesis is divided in two studies with the commune aim of elucidating the molecular mechanisms of albumin on leukocytes, in the context of advanced liver cirrhosis. The first study ...
Torrens Fontanals, Laura (Fecha de defensa: 2022-03-07)
[eng] 1. HYPOTHESES. Primary liver cancer is the sixth most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide2,3. Around 90% of cases correspond to hepatocellular ...
Catalán García, Marc (Fecha de defensa: 2017-03-20)
Sporadic inclusion body myositis (sIBM) is the most common myopathy in elderly. This disease causes muscle wasting with both distal and proximal affectation. Quadriceps and finger flexors are muscle ...
Rofes Terrón, Paula (Fecha de defensa: 2022-03-31)
The overarching aim of the present thesis project is to implement new testing strategies and develop new tools that will contribute to improve the genetic diagnosis of hereditary cancer, with the ultimate ...
Solé Font, Laura (Fecha de defensa: 2021-07-02)
Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that eradicate highly proliferative malignant cells. Whether sublethal chemotherapy affects tumour cell behaviour and ...
Profitós Pelejà, Núria (Fecha de defensa: 2020-07-29)
ZEB1 and ZEB2 are two transcription factors best known for their role driving a dedifferentiation process, commonly referred as epithelial to mesenchymal transition (EMT). This process is carried out ...
Baroni, Matteo Libero (Fecha de defensa: 2020-07-17)
[eng] Resistance to standard therapy and relapses are observed in several cases of both myeloid and lymphoid cell malignancies. Such phenomenon poses unquestionable limits to the utility of current ...
Cabot, Débora (Fecha de defensa: 2020-09-28)
[eng] Analysis of KRAS phosphorylation and KRAS effector domain as targets for cancer therapy Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer (CRC). ...