Anlas, Kerim (Date of defense: 2022-07-06)
Across metazoans, minimal in vitro systems from embryonic stem cells (ESCs) recapitulate the establishment of a body plan, particularly the anteroposterior (AP) axis. In contrast to actual embryos that ...
Carrillo García, Julia (Date of defense: 2021-09-30)
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay ...
Higuera González, Laura (Date of defense: 2021-10-01)
Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network ...
Ollé Vila, Aina (Date of defense: 2020-02-12)
Les grans transicions evolutives han transformat profundament la manera com la informació s'organitza i es transmet, a vegades en la forma d'un nou nivell jeràrquic que conté entitats que prèviament es ...
Bonforti, Adriano (Date of defense: 2022-07-27)
L'aparició de la pluricel·lularitat (MC) va definir un esdeveniment evolutiu important en la història de la vida al nostre planeta. Ha tingut lloc diverses vegades dins de grups independents i diferents ...
Torcal Garcia, Guillem (Date of defense: 2022-02-10)
Lineage-instructive transcription factors orchestrate cell fate decisions by regulating gene expression programs. However, how their function is regulated throughout development is poorly understood. ...
Pijuan Calvet, Anna (Date of defense: 2021-09-14)
Yeast deal with continuous environmental perturbations that compromise its cell fitness. Upon osmostress, HOG pathway becomes activated and leads the adaptation response. To compensate the osmotic ...
Martinez Sarmiento, Jose Angel (Date of defense: 2023-05-04)
Elucidating the mechanism of somatic cell reprogramming has been hampered by the limitations of iPSC systems to uncover the correctly reprogramming cells. Here, by using the highly efficient heterokaryon ...
Salat Canela, Clàudia (Date of defense: 2020-09-30)
Living organisms must respond to changes in their environment in order to overcome stress situations. In Schizosaccharomyces pombe, Sty1 MAP kinase is required to survive to a wide range of environmental ...
Herrero Vicente, Jorge (Date of defense: 2024-02-26)
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible ...