López Polo, Vanessa (Date of defense: 2024-03-07)
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the ...
Condemi, Livia (Date of defense: 2024-03-07)
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex ...
Hong, Xiaotong (Date of defense: 2022-10-06)
La regeneración del músculo esquelético depende de la expansión correcta de las células madre inactivas residentes (células satélite), un proceso que se vuelve menos eficiente con el envejecimiento, por ...
Vineethakumari Muraleedharan, Chithran (Date of defense: 2024-03-14)
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting ...
Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Suárez Ara, Patricia (Date of defense: 2024-04-12)
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel ...
Aguilar Fernández, Sergio (Date of defense: 2024-04-24)
The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation ...
Dhandapani, Laasya (Date of defense: 2022-05-04)
En este proyecto, hemos desarrollado métodos que permiten la caracterización comparativa basada en imágenes en vivo de ovocitos primordiales de humano, ratón y Xenopus. Mostramos que los ovocitos ...
Piñero, Jordi (Date of defense: 2023-05-08)
This thesis aims at establishing the basis for a statistical physics theory of major evolutionary transitions. Its structure is based on three major pillars: nonequilibrium thermodynamics and information ...
Ramírez Cuéllar, Angélica Julieta (Date of defense: 2022-05-12)
In this Thesis we report the successful growth of hormone responsive T47D cells as 3D spheroids in Matrigel mimicking the ECM. A detailed characterization by using a genome-wide approach of the main ...