Martín Rodríguez, Elena (Date of defense: 2018-01-24)
A splicing network analysis that captured functional similarities among spliceosomal components, revealed a prominent core module containing splicing factors SPF45, SR140 and CHERP. We report that ...
Agirre Ortiz de Guzmán, Eneritz (Date of defense: 2013-06-21)
Generalment s'ha pensat que la regulació de l'splicing alternatiu està controlada principalment per la interacció entre els factors reguladors de l'splicing i la taxa d'elongació de la ARN polimerasa ...
Kremsky, Isaac Jacob (Date of defense: 2015-07-14)
Proteins that bind to DNA or RNA are both known to influence alternative splicing. However, there has not been so far a systematic experimental exploration of the relationship between these factors ...
Wyatt, Christopher Douglas Robert (Date of defense: 2019-06-19)
The transition from maternal to embryonic control is a crucial time in an organism’s life cycle, with an overhaul of the epigenetic marks, targeted mRNA degradation and the initiation of transcription. ...
Ciampi, Ludovica (Date of defense: 2023-04-27)
The nervous system comprises an immense number of cells that serve highly specialized roles. Accordingly, they possess unique morphological and functional attributes, greatly shaped by specific Alternative ...
Hernández Ribera, Jordi (Date of defense: 2016-11-23)
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative ...
Vigevani, Luisa (Date of defense: 2016-11-21)
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor ...
Aya Moreno, Francisco (Date of defense: 2023-02-15)
Alternative splicing of BRAF mRNA can provide a resistance mechanism to BRAF and MEK inhibitors that has been described mostly in BRAF-mutant melanoma. The mechanisms underlying the production of a ...
Baeza Centurión, Pablo (Date of defense: 2020-02-27)
Alternative pre-mRNA splicing is a regulated step in eukaryotic gene expression in which introns are removed from the transcript and exons are joined together to form a mature mRNA. To study the effects ...
Garrido Martín, Diego (Date of defense: 2020-01-30)
We have developed an efficient and reproducible pipeline for the identification of genetic variants affecting splicing (splicing quantitative trait loci or sQTLs), based on an approach that captures the ...
575 - General genetics. General cytogenetics (9)
576 - Cellular and subcellular biology. Cytology (5)
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics (4)
616.6 - Pathology of the urogenital system. Urinary and sexual (genital) complaints. Urology (2)