Obiols Guardia, Aida (Date of defense: 2020-07-17)
Diversos estudios transcripcionales actuales ponen de manifiesto la importancia funcional de la porción no codificante de nuestro genoma, observándose un papel crucial en todos los niveles de la regulación ...
Rosselló Tortella, Margalida (Date of defense: 2021-12-09)
Transfer RNAs (tRNAs) are essential molecules that allow the translation of the genetic code into amino acids. Extensive research during the last 50 years have revealed that, despite their apparently ...
Szczesna, Karolina (Date of defense: 2014-09-26)
INTRODUCTION: In 1966, Rett syndrome (RTT, OMIM#312750) was for the first time described as a clinical issue by Dr. Andreas Rett, an Austrian pediatrician. He has observed in 22 patients similar ...
Pérez Salvia, Montserrat (Date of defense: 2019-03-01)
Cancer is considered nowadays a genetic and epigenetic disease. Aberrancies in epigenetic marks in DNA and histone tails together with alterations in epigenetic regulators responsible of catalyzing ...
Lucariello, Mario (Date of defense: 2017-03-16)
STUDY I HYPOTHESIS Genetic alterations have already been recognized as major etiological factors for ASD and ID, of which RTT is an example. In addition to the contribution of polymorphic variants ...
Oliveira Mateos, Cristina (Date of defense: 2020-06-16)
The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory ...
Ortiz Barahona, Vanessa (Date of defense: 2022-04-01)
The general aim of this thesis is to identify and characterize if there are DNA methylation patterns giving rise to cancer-related m5C RNA modification defects, potentially promoting malignant transformation ...
Coll San Martín, Laia (Date of defense: 2021-11-29)
Cancer was reported as the second leading cause of death in 2018 by the World Health Organisation. Cancer is defined as the set of diseases that proceeds in multiple phases generating a transformation ...
Soler Riera, Marta (Date of defense: 2023-02-24)
[cat] Els RNAs no codificants tenen un paper important com a reguladors de les funcions biològiques del desenvolupament i la fisiologia, i per tant la seva desregulació pot tenir un impacte en diverses ...
Petazzi, Paolo (Date of defense: 2015-02-20)
INTRODUCTION To answer many complex and fascinating biological phenomena, we must go over or above (epi-) genetics because the DNA blueprint is identical in each of the abovementioned somatic cells. ...