Mostrando ítems 1-8 de 8
Mendive Tapia, Lorena (Fecha de defensa: 2017-02-17)
In the present thesis we have investigated the development of new methodologies for the selective and straightforward chemical modification of Trp amino acid either alone or in peptides. In the first ...
Palà Pujadas, Judith (Fecha de defensa: 2018-03-12)
Chemical protein synthesis has become a potent tool for the synthesis of proteins, especially those which are not easily accessed by DNA recombinant methods, such as proteins with posttranslational ...
Fernández-Llamazares Onrubia, Ana Iris (Fecha de defensa: 2013-12-09)
Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational ...
Postma, Tobias Maria (Fecha de defensa: 2014-03-21)
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. ...
Zamudio Vázquez, Rubí (Fecha de defensa: 2014-02-14)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit ...
Góngora Benítez, Miriam (Fecha de defensa: 2013-02-08)
Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during ...
Mas Moruno, Carlos (Fecha de defensa: 2009-03-05)
La sepsis es un síndrome muy complejo de definir, diagnosticar y tratar. La patología de la sepsis se deriva de una respuesta perjudicial del organismo a una infección. La exposición a endotoxinas ...
Herraiz Cobo, Jesús (Fecha de defensa: 2017-07-13)
Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy ...