Modulation of the RNAi pathway by chemically modified siRNA molecules 

Alagia, Adele (Fecha de defensa: 2015-12-11)

To direct post-transcriptionally gene silencing, RNAi machinery exploits the formation of base pairs between the loaded guide strand and the complementary mRNA. The Ago2 protein is the “slicer” effector of the RISC and ...