Universitat Pompeu Fabra
Now showing items 2506-2525 of 3216
El catalanisme polític es consolida en el període que va entre la crisi de finals de segle i la constitució de la Solidaritat Catalana. La plena participació en la política institucional ve acompanyada d’una reelaboració ...
El mal pronòstic en una neoplàsia epitelial està associada a l'adquisició de característiques mòbils o invasives per part de les cèl·lules canceroses. Aquesta transformació morfològica es denomina transició epiteli-mesènquima ...
Las especies reactivas del oxígeno (ROS), superóxido (O2o-), peróxido de hidrógeno (H2O2), y radical hidroxilo (OHo), se generan a partir de la reducción parcial del oxígeno molecular durante procesos metabólicos como la ...
Cells have the ability to respond and adapt to environmental changes through activation of stress-activated protein kinases (SAPKs). Activation of the p38 SAPK is critical to elicit the early gene expression program required ...
The vertebrate inner ear is the organ responsible for the senses of balance, acceleration and audition. Three cell types form the functional unit of the ear: hair cells, neurons and supporting cells. Atoh1 and Neurog1, two ...
Immunoglobulin (Ig) diversification is essential for the generation of protective immune responses against intruding microbes. B cells require cognate interaction with T cells to generate protective antibodies, although ...
The large-conductance Ca2+- and voltage-gated K+ (BK) channel containing the pore-forming and the regulatory B1 subunits play a pivotal role in the control of arterial tone and modification of channel function is associated ...
Yeast deal with continuous environmental perturbations that compromise its cell fitness. Upon osmostress, HOG pathway becomes activated and leads the adaptation response. To compensate the osmotic imbalance, Hog1 is in ...
The p38 mitogen activated protein kinase (MAPK) has a crucial role in cells’ stress adaptation and survival. It also plays a role in physiological processes such as differentiation of skeletal muscle or in pathologies such ...
Reactive oxygen species (ROS) are a variety of molecules derived from molecular oxygen during different metabolic processes. ROS can react with different cellular components resulting in lipid peroxidation, protein oxidation ...
This thesis consists of three essays on the regulation of Intellectual Property Rights (IPRs) and trade in open economies. The rst chapter investigates the di erences in Intellectual Property Rights between countries. ...
Alternative splicing provides the cell the ability to generate, from a single gene, multiple protein isoforms, sometimes with different or even antagonistic functions. This process is tightly regulated and alterations in ...
This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell ...
NFAT5 is the main regulator of an osmoprotective gene program that is switched on by osmotic stress. Hypertonicity causes a harmful increase in the intracellular concentration of inorganic ions and NFAT5-regulated genes ...
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative splicing regulation ...
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of ...
CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
El gen humano 11-HSD2 es un modelo para investigar la contribución de los efectos de los receptores de esteroides en células de cáncer de mama. El análisis del promotor mostró que la región distal está implicada ...
DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs are activated by ...
A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió gènica, que es ...
