Ivancic, Dimitrie (Date of defense: 2024-04-03)
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome ...
Özer, Ege Ekin (Date of defense: 2024-03-21)
In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. ...
Bajew, Simon (Date of defense: 2022-04-12)
Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This ...
Shekari, Mahnaz (Date of defense: 2024-04-03)
This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the ...
Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Delgado Tejedor, Anna (Date of defense: 2024-03-21)
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. ...
Morales Pastor, Adrián (Date of defense: 2024-04-11)
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation ...
Suárez Ara, Patricia (Date of defense: 2024-04-12)
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel ...
Vandelli, Andrea (Date of defense: 2023-04-19)
Ribonucleoprotein condensates such as stress granules (SGs) and processing bodies (PBs) form in response to specific stimuli in the cell. Even though the key protein and RNA elements of these condensates ...
Santamaría Martínez, Mezteli Suyapa (Date of defense: 2023-02-08)
In the last couple of years, medical information has been presented across different digital and visual forms of communication. Mainly, comics are published on various social media platforms and ...